Roussel S, Pinard E, Seylaz J
Laboratoire de Physiologie et Physiopathologie cérébrovasculaire, U. 182 I.N.S.E.R.M., Paris, France.
Brain Res. 1990 Jun 4;518(1-2):353-5. doi: 10.1016/0006-8993(90)90997-p.
The effects of the excitatory amino acid receptor antagonist, kynurenate, were investigated in spontaneously hypertensive rats after middle cerebral artery occlusion. Kynurenate did not significantly modify either the infarct volume, measured 48 h after occlusion, or the neurological score. The absence of a neuroprotective effect of kynurenate in this study, which contrasts with results in normotensive rats, is suggested to be due to impaired collateral circulation in spontaneously hypertensive rats.
在大脑中动脉闭塞后的自发性高血压大鼠中，研究了兴奋性氨基酸受体拮抗剂犬尿烯酸的作用。犬尿烯酸对闭塞48小时后测量的梗死体积或神经学评分均无显著影响。本研究中犬尿烯酸缺乏神经保护作用，这与正常血压大鼠的结果形成对比，提示其原因是自发性高血压大鼠的侧支循环受损。
