NIH/NIAID/Laboratory of Malaria Immunology and Vaccinology, Rockville, MD 20852, USA.
AIDS. 2013 Jun 19;27(10):1674-7. doi: 10.1097/QAD.0b013e3283621dd4.
HIV and malaria overlap geographically, but the full impact of different antiretrovirals on malaria remains poorly understood. We examined the antimalarial activity of the HIV protease inhibitors lopinavir and saquinavir and the non-nucleoside reverse transcriptase inhibitor nevirapine on Plasmodium falciparum liver stages. Our results demonstrate that the HIV PI lopinavir inhibits liver stage parasites at clinically relevant concentrations, that is, at drug levels achieved in HIV-infected patients on standard dosing regimens. Because drugs that inhibit liver stages target parasites when they are present in lower numbers, these results might have implications for eradication efforts.
HIV 和疟疾在地理上有重叠，但不同抗逆转录病毒药物对疟疾的全面影响仍知之甚少。我们研究了 HIV 蛋白酶抑制剂洛匹那韦和沙奎那韦以及非核苷类逆转录酶抑制剂奈韦拉平对疟原虫肝期的抗疟活性。我们的结果表明，HIV PI 洛匹那韦以临床相关浓度（即 HIV 感染患者在标准剂量方案下达到的药物水平）抑制肝期寄生虫。由于抑制肝期的药物在寄生虫数量较少时靶向寄生虫，因此这些结果可能对根除工作有影响。
