Department of Epidemiology, GROW School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands,
Cancer Causes Control. 2013 Nov;24(11):1947-54. doi: 10.1007/s10552-013-0270-5. Epub 2013 Aug 2.
Bioactive compounds found in coffee and tea may delay the progression of prostate cancer.
We investigated associations of pre-diagnostic coffee and tea consumption with risk of prostate cancer recurrence/progression. Study participants were men diagnosed with prostate cancer in 2002-2005 in King County, Washington, USA. We assessed the usual pattern of coffee and tea consumption two years before diagnosis date. Prostate cancer-specific outcome events were identified using a detailed follow-up survey. Multivariable Cox proportional hazards regression models were used to estimate hazard ratios (HRs) and 95 % confidence intervals (CIs).
The analysis of coffee intake in relation to prostate cancer recurrence/progression included 630 patients with a median follow-up of 6.4 years, during which 140 prostate cancer recurrence/progression events were recorded. Approximately 61 % of patients consumed at least one cup of coffee per day. Coffee consumption was associated with a reduced risk of prostate cancer recurrence/progression; the adjusted HR for ≥4 cups/day versus ≤1 cup/week was 0.41 (95 % CI: 0.20, 0.81; p for trend = 0.01). Approximately 14 % of patients consumed one or more cups of tea per day, and tea consumption was unrelated to prostate cancer recurrence/progression.
Results indicate that higher pre-diagnostic coffee consumption is associated with a lower risk of prostate cancer recurrence/progression. This finding will require replication in larger studies.
咖啡和茶中的生物活性化合物可能会延缓前列腺癌的进展。
我们研究了诊断前咖啡和茶的消耗与前列腺癌复发/进展风险之间的关联。研究参与者为 2002-2005 年在美国华盛顿州金县诊断出前列腺癌的男性。我们评估了诊断前两年的咖啡和茶的通常消耗模式。使用详细的随访调查确定前列腺癌特异性结局事件。多变量 Cox 比例风险回归模型用于估计风险比 (HR) 和 95%置信区间 (CI)。
分析咖啡摄入与前列腺癌复发/进展的关系包括 630 名患者，中位随访时间为 6.4 年，在此期间记录了 140 例前列腺癌复发/进展事件。大约 61%的患者每天至少喝一杯咖啡。咖啡消耗与前列腺癌复发/进展的风险降低有关；每天≥4 杯与每周≤1 杯的调整 HR 为 0.41（95%CI：0.20，0.81；趋势检验 p=0.01）。大约 14%的患者每天饮用一杯或更多杯茶，而茶的消耗与前列腺癌复发/进展无关。
结果表明，较高的诊断前咖啡消耗与前列腺癌复发/进展的风险降低相关。这一发现需要在更大的研究中进行复制。
