动物研究中的伦理考量。
Ethical considerations in animal studies.
作者信息
Ghasemi Mehdi, Dehpour Ahmad Reza
机构信息
Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, P.O. Box 13145-784, Tehran, Iran.
出版信息
J Med Ethics Hist Med. 2009 Jul 30;2:12. Print 2009.
Abstract
Scientists undoubtedly owe their great advance and knowledge in biomedical research to millions of animals which they use every year in often-times extremely painful and distressing scientific procedures. One of the important issues in scientific research is to consider ethics in animal experimentation. Since this is a crucial issue in the modern era of medical research, in this paper, we have provided some guidelines (most of which have been adopted from Guidelines for Ethical Conduct in the Care and Use of Animals provided by American Association of Psychologists) which could be useful for researchers to design studies on a variety of animals.
摘要
科学家们在生物医学研究中取得的巨大进步和知识无疑要归功于他们每年在常常极其痛苦和令人痛苦的科学实验中使用的数百万只动物。科学研究中的一个重要问题是在动物实验中考虑伦理道德。由于这是现代医学研究时代的一个关键问题，在本文中，我们提供了一些指导方针（其中大部分借鉴了美国心理协会提供的《动物饲养和使用中的伦理行为准则》），这些指导方针可能有助于研究人员设计针对各种动物的研究。
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本文引用的文献
1
Envisaging the embryo in stem cell research: rhetorical strategies and media reporting of the ethical debates.干细胞研究中的胚胎设想：伦理辩论的修辞策略与媒体报道
Sociol Health Illn. 2003 Nov;25(7):793-814. doi: 10.1046/j.1467-9566.2003.00370.x.
2
Animal biotechnology: how not to presume.动物生物技术：切勿妄下定论。
Am J Bioeth. 2008 Jun;8(6):49-50. doi: 10.1080/15265160802248278.
3
Animal research: the debate continues.动物研究：争论仍在继续。
J Intern Med. 2007 Dec;262(6):591-2. doi: 10.1111/j.1365-2796.2007.01884.x.
4
The ethics of animal experimentation.动物实验的伦理问题。
Emerg Med J. 2007 Nov;24(11):750-1. doi: 10.1136/emj.2007.050146.
5
The ethics of animal research. Talking Point on the use of animals in scientific research.动物研究的伦理。关于在科学研究中使用动物的讨论要点。
EMBO Rep. 2007 Jun;8(6):526-30. doi: 10.1038/sj.embor.7400993.
6
Animal research: the debate continues.动物研究：争论仍在继续。
Lancet. 2007 Apr 7;369(9568):1147-8. doi: 10.1016/S0140-6736(07)60541-8.
7
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8
Marginal cases and moral relevance.边缘案例与道德相关性。
J Soc Philos. 2002 Winter;33(4):523-39. doi: 10.1111/1467-9833.00155.
9
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