Mishmar Dan
Department of Life Sciences and the National Institute of Biotechnology (NIBN), Ben-Gurion University of the Negev, Beer Sheva, Israel.
Rambam Maimonides Med J. 2010 Jul 2;1(1):e0010. doi: 10.5041/RMMJ.10010. Print 2010 Jul.
Complex disorders are common in the human population and are caused by interplay between genetic and environmental factors. Therefore the quest for the genetic basis of such disorders has much similarity to deciphering the genetic basis of macro-evolutionary processes, such as speciation. Here I discuss conceptual connections between the principles underlying and processes occurring in disease and evolution. Special focus is given to the tremendous mitochondrial genetic variability in the population and within individuals and the impact of both types of variability on evolutionary processes and diseases.
复杂疾病在人类群体中很常见，是由遗传和环境因素相互作用引起的。因此，探寻此类疾病的遗传基础与解读宏观进化过程（如物种形成）的遗传基础有许多相似之处。在此，我将讨论疾病和进化背后的原理及发生过程之间的概念联系。特别关注群体中和个体内巨大的线粒体遗传变异性，以及这两种变异性对进化过程和疾病的影响。
