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重症肌无力患者红细胞免疫功能及循环免疫复合物的检测

[Detection of erythrocyte immune function and circulatory immune complex in myasthenia gravis].

作者信息

Guo F

机构信息

Laboratory of Immunology, Changhai Hospital, Second Military College Shanghai.

出版信息

Zhonghua Shen Jing Jing Shen Ke Za Zhi. 1990 Jun;23(3):133-5, 188.

PMID:2390883
Abstract

The circulating immune complexes (CIC) and erythrocyte immune function in myasthenia gravis were studied. In order to examine CIC in the patients with myasthenia gravis the complement sensitized yeast cell agglutination (CSYCA) test and anti-C3-ELISA were used. The CIC positive rate was 92.3% in the patients tested. The CIC test was all negative in the normal control subjects. The levels of CIC were remarkable elevated in the patients with myasthenia gravis (P less than 0.01). It was found that the rosette rate of red blood cell C3b receptor was 11.27 +/- 3.27% in the CIC negative patients with myasthenia gravis and 17.60 +/- 5.10% in CIC negative patients with myasthenia gravis. The erythrocyte immune function decreased remarkably in the CIC positive patients with myasthenia gravis (P less than 0.05). The relationship between the decrease of the erythrocyte immune function and myasthenia gravis is discussed.

摘要

对重症肌无力患者的循环免疫复合物(CIC)及红细胞免疫功能进行了研究。为检测重症肌无力患者的CIC,采用了补体致敏酵母细胞凝集(CSYCA)试验和抗C3-ELISA法。受试患者的CIC阳性率为92.3%。正常对照者的CIC检测均为阴性。重症肌无力患者的CIC水平显著升高(P<0.01)。发现CIC阴性的重症肌无力患者红细胞C3b受体花环率为11.27±3.27%,CIC阳性的重症肌无力患者为17.60±5.10%。CIC阳性的重症肌无力患者红细胞免疫功能明显降低(P<0.05)。并对红细胞免疫功能降低与重症肌无力之间的关系进行了讨论。

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