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石榴有益心血管健康。

Pomegranate for your cardiovascular health.

作者信息

Aviram Michael, Rosenblat Mira

机构信息

The Lipid Research Laboratory, The Rappaport Faculty of Medicine and Research Institute, Technion-Institute of Technology, and Rambam Medical Center, Haifa, Israel.

出版信息

Rambam Maimonides Med J. 2013 Apr 30;4(2):e0013. doi: 10.5041/RMMJ.10113. Print 2013 Apr.

Abstract

Pomegranate is a source of some very potent antioxidants (tannins, anthocyanins) which are considered to be also potent anti-atherogenic agents. The combination of the above unique various types of pomegranate polyphenols provides a much wider spectrum of action against several types of free radicals. Indeed, pomegranate is superior in comparison to other antioxidants in protecting low-density lipoprotein (LDL, "the bad cholesterol") and high-density lipoprotein (HDL, "the good cholesterol") from oxidation, and as a result it attenuates atherosclerosis development and its consequent cardiovascular events. Pomegranate antioxidants are not free, but are attached to the pomegranate sugars, and hence were shown to be beneficial even in diabetic patients. Furthermore, pomegranate antioxidants are unique in their ability to increase the activity of the HDL-associated paraoxonase 1 (PON1), which breaks down harmful oxidized lipids in lipoproteins, in macrophages, and in atherosclerotic plaques. Finally, unique pomegranate antioxidants beneficially decrease blood pressure. All the above beneficial characteristics make the pomegranate a uniquely healthy fruit.

摘要

石榴富含一些非常强效的抗氧化剂(单宁、花青素),这些抗氧化剂也被认为是强效的抗动脉粥样硬化剂。上述独特的各类石榴多酚相结合,对多种自由基具有更广泛的作用谱。事实上,与其他抗氧化剂相比,石榴在保护低密度脂蛋白(LDL,“坏胆固醇”)和高密度脂蛋白(HDL,“好胆固醇”)免受氧化方面更具优势,因此它能减缓动脉粥样硬化的发展及其引发的心血管事件。石榴中的抗氧化剂并非游离状态,而是与石榴糖分结合,因此即使对糖尿病患者也显示出有益效果。此外,石榴抗氧化剂的独特之处在于能够增强与高密度脂蛋白相关的对氧磷酶1(PON1)的活性,该酶可分解脂蛋白、巨噬细胞和动脉粥样硬化斑块中的有害氧化脂质。最后,独特的石榴抗氧化剂能有效降低血压。上述所有有益特性使石榴成为一种极为健康的水果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a83b/3678830/0203aaf03d80/rmmj-4-2-e0013_Figure01.jpg

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