State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 100871, China.
J Biomed Nanotechnol. 2013 Jul;9(7):1155-63. doi: 10.1166/jbn.2013.1611.
A pH-triggered drug delivery system that can specially target to folate-receptors-overexpressing cancer cells was designed based on newly developed polydopamine capsules and folic acid. The polycapsules bioconjugates possess capabilities of high drug loading, enhanced folate-receptor-mediated cell uptake, and sustained drug release by intracellular pH changes. It was also found that the sustained release of drugs significantly increased reactive oxygen species (ROS) level in targeted cells. The efficient cell-specific endocytosis and intracellular pH-responsive controlled drug delivery of the capsules is promising for future in vivo therapeutic applications.
基于新开发的聚多巴胺胶囊和叶酸，设计了一种 pH 触发的药物传递系统，该系统可以专门针对叶酸受体过表达的癌细胞。聚胶囊生物缀合物具有高载药能力、增强叶酸受体介导的细胞摄取能力以及通过细胞内 pH 变化实现的药物持续释放能力。还发现，药物的持续释放显著增加了靶细胞中的活性氧 (ROS) 水平。胶囊的高效细胞特异性内吞作用和细胞内 pH 响应控制药物递送对于未来的体内治疗应用具有广阔的前景。
