Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne, Switzerland.
Eur J Clin Invest. 2013 Sep;43(9):978-85. doi: 10.1111/eci.12117. Epub 2013 Jun 12.
The renin-angiotensin system (RAS) has been shown to play an active role within the erectile tissues. The aim of this narrative review is to summarize the literature addressing the pathophysiological role of RAS on erectile function. Additionally, we update evidence on recent findings on the role of the Ang-(1-7) and Mas receptor on the erectile function and its therapeutic potential for treating erectile dysfunction (ED).
This narrative review is based on the material searched and obtained via MEDLINE and PubMed up to November 2012. The search terms we used are 'angiotensin, erectile dysfunction, renin, Mas receptor' in combination with 'pathophysiology, fibrosis, pathways'.
The levels of angiotensin (Ang) II, the main component of this system, are increased in the corpus cavernosum as compared to those found in the systemic circulation. Moreover, emerging evidence indicates that an increased activity of Ang II via AT1 receptor might contribute to the development of ED, whereas the pharmacological blockage of Ang II/AT1 actions has beneficial effects on the erection. On the other hand, the heptapeptide Ang-(1-7), known as a major endogenous counter-regulator of Ang II actions, favours penile erection via the activation of Mas receptor.
Ang-(1-7) and Mas receptor pathway might be considered as a promising therapeutic target for the treatment of ED.
肾素-血管紧张素系统（RAS）在勃起组织中发挥着积极的作用。本综述的目的是总结有关 RAS 对勃起功能的病理生理作用的文献。此外，我们还更新了有关 Ang-(1-7)和 Mas 受体在勃起功能及其治疗勃起功能障碍（ED）的潜在治疗作用的最新发现的证据。
本综述基于通过 MEDLINE 和 PubMed 搜索并获得的资料，截至 2012 年 11 月。我们使用的搜索词是“angiotensin，erectile dysfunction，renin，Mas receptor”，与“pathophysiology，fibrosis，pathways”相结合。
血管紧张素（Ang）II 的水平，即该系统的主要成分，在海绵体中比在全身循环中增加。此外，新出现的证据表明，通过 AT1 受体增加 Ang II 的活性可能有助于 ED 的发展，而 Ang II/AT1 作用的药理学阻断对勃起具有有益的影响。另一方面，七肽 Ang-(1-7)，作为 Ang II 作用的主要内源性拮抗物，通过激活 Mas 受体有利于阴茎勃起。
Ang-(1-7)和 Mas 受体途径可能被认为是治疗 ED 的有前途的治疗靶点。
