van Bel F, van de Bor M, Stijnen T, Baan J, Ruys J H
Department of Pediatrics (Neonatal Unit), University Hospital of Leiden, The Netherlands.
Eur J Pediatr. 1987 Sep;146(5):461-7. doi: 10.1007/BF00441595.
In a controlled study serial determinations of cerebral blood flow velocity using Doppler ultrasound and repeated real-time ultrasonographic- or computerized axial tomographic studies of the brain were performed in 17 (nearly) full-term newborns who experienced perinatal asphyxia and in 17 healthy matched controls during the first week of life. A higher cerebral blood flow velocity was found during the first 4 days of life, indicating a lower cerebrovascular resistance in the asphyxiated infants compared to the control infants. These haemodynamic changes coincided with cerebral oedema and neurological abnormalities. It is speculated that the changes in the cerebral circulation in asphyxiated infants are at least partly caused by cerebral oedema-induced increase of intracranial pressure due to severe perinatal asphyxia. Serial Doppler ultrasound investigations of the brain may be a useful non-invasive method for early detection and follow-up of the consequences of severe perinatal asphyxia.
在一项对照研究中，对17名（近）足月新生儿进行了围产期窒息，在出生后第一周，使用多普勒超声对其脑血流速度进行了系列测定，并对其大脑进行了重复的实时超声或计算机断层扫描研究，同时选取了17名健康的匹配对照进行同样的研究。在出生后的头4天发现窒息婴儿的脑血流速度较高，这表明与对照婴儿相比，窒息婴儿的脑血管阻力较低。这些血流动力学变化与脑水肿和神经学异常同时出现。据推测，窒息婴儿脑循环的变化至少部分是由严重围产期窒息导致的脑水肿引起的颅内压升高所致。对大脑进行系列多普勒超声检查可能是一种有用的非侵入性方法，用于早期检测和随访严重围产期窒息的后果。
