Department of Plant Developmental Biology, Max Planck Institute for Plant Breeding Research, D-50829 Cologne, Germany.
Trends Plant Sci. 2013 Nov;18(11):633-43. doi: 10.1016/j.tplants.2013.07.001. Epub 2013 Jul 30.
Post-translational modifications of the carboxy-terminal domain of the largest subunit of RNA polymerase II (RNAPII CTD) provide recognition marks to coordinate recruitment of numerous nuclear factors controlling transcription, cotranscriptional RNA processing, chromatin remodeling, and RNA export. Compared with the progress in yeast and mammals, deciphering the regulatory roles of position-specific combinatorial CTD modifications, the so-called CTD code, is still at an early stage in plants. In this review, we discuss some of the recent advances in understanding of the molecular mechanisms controlling the deposition and recognition of RNAPII CTD marks in plants during the transcriptional cycle and highlight some intriguing differences between regulatory components characterized in yeast, mammals, and plants.
RNA 聚合酶 II 大亚基羧基末端结构域（RNAPII CTD）的翻译后修饰为协调募集大量核因子提供了识别标记，这些核因子控制转录、共转录 RNA 加工、染色质重塑和 RNA 输出。与酵母和哺乳动物的研究进展相比，解析位置特异性组合 CTD 修饰（所谓的 CTD 密码）的调控作用在植物中仍处于早期阶段。在这篇综述中，我们讨论了在转录周期中理解控制植物中 RNAPII CTD 标记沉积和识别的分子机制的一些最新进展，并强调了在酵母、哺乳动物和植物中鉴定的调控成分之间存在一些有趣的差异。
