Díaz Morales Olga, Martinez-Pajares José David, Trigo Moreno Juan, Ramos Díaz Juan Carlos
Unidad de Gestión Clínica de Pediatría, Hospital General de Antequera, Málaga, España.
Arch Argent Pediatr. 2013 Jul-Aug;111(4):e97-100. doi: 10.5546/aap.2013.e97.
The introduction of routine vaccination against whooping cough caused a drastic decline in the incidence of this disease, but remains today a public health problem even in countries with high vaccination coverage. However, with this decrease in cases, there were an emergence of neurological severe adverse events such as the "hypotonic-hyporesponsive episodes" (HHE), characterized by sudden loss of muscle tone associated with poor response to stimuli and skin pallor or cyanosis. The HHE is a rare phenomenon after administration of pertussis vaccine, but it is essential for health workers recognition of such reactions, especially in the 48 hours following vaccination. Although sometimes can become difficult to attribute a causal relationship between vaccine administration and an adverse effect, any suspicious events should be reported.
百日咳常规疫苗接种的引入使该疾病的发病率急剧下降，但即便在疫苗接种覆盖率高的国家，百日咳如今仍是一个公共卫生问题。然而，随着病例数的减少，出现了一些严重的神经系统不良事件，如“低张-低反应性发作”（HHE），其特征为肌张力突然丧失，对刺激反应不佳，皮肤苍白或发绀。HHE是接种百日咳疫苗后罕见的现象，但医护人员认识到这类反应至关重要，尤其是在接种疫苗后的48小时内。尽管有时难以确定疫苗接种与不良反应之间的因果关系，但任何可疑事件都应上报。
