Immunology lecturer, Radiation Safety Department, National Center for Nuclear Safety and Radiation Control, Egyptian Atomic Energy Authority/ Egyptian Nuclear and Radiological Regulatory Authority, 3 Ahmed Elzomor Str., 11762, P.O. Box 7551, Nasr City, Cairo, Egypt.
Cell Biochem Biophys. 2021 Dec;79(4):887-894. doi: 10.1007/s12013-021-01017-5. Epub 2021 Jul 5.
Ionizing radiation (IR) is used in a wide range of clinical applications. The study aims to evaluate various IR doses for their immunomodulatory responses, which can be used in multiple immunological conditions. Forty rats were exposed to whole-body gamma rays of 0, 0.25, 0.5, and 1 Gray (Gy). T-cell receptor (TCR) gene expression, serum transforming growth factor-beta, interleukin-10 (IL-10), and nitric oxide levels were measured on days 1 and 4 post irradiation. TCR activation occurred only at the genetic level, and radiation raised all measured parameters, even at low doses at α = 0.05 (P < 0.05). Except for IL-10, it shows a nearly 6% (P < 0.05) rise in early response in irradiated groups up to 0.5 Gy. At lower doses, the indirect impacts of IR were as essential as the direct impacts, and they increased over time in most measured parameters due to endogenous releases. They were having an anti-proliferative effect on the immune system. Lastly, a single acute IR dose can raise anti-inflammatory cytokines and anti-proliferative effects in the immune system, avoiding various contraindications associated with immunomodulatory drugs. More information on safety and clinical relevance is needed.
电离辐射（IR）在广泛的临床应用中得到了应用。本研究旨在评估各种 IR 剂量的免疫调节反应，这些反应可用于多种免疫状况。40 只大鼠接受了 0、0.25、0.5 和 1 戈瑞（Gy）的全身γ射线照射。在照射后第 1 天和第 4 天测量 T 细胞受体（TCR）基因表达、血清转化生长因子-β、白细胞介素-10（IL-10）和一氧化氮水平。TCR 激活仅发生在基因水平，辐射提高了所有测量的参数，即使在低剂量下也达到了 α=0.05（P<0.05）。除了 IL-10，在 0.5Gy 以下的照射组中，早期反应的上升幅度接近 6%（P<0.05）。在较低的剂量下，IR 的间接影响与直接影响一样重要，由于内源性释放，它们在大多数测量的参数中随时间增加。它们对免疫系统具有抗增殖作用。最后，单次急性 IR 剂量可提高免疫系统中的抗炎细胞因子和抗增殖作用，避免与免疫调节药物相关的各种禁忌症。需要更多关于安全性和临床相关性的信息。
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