Oncology Diagnostic Unit, Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Med Oncol. 2013;30(3):673. doi: 10.1007/s12032-013-0673-x. Epub 2013 Aug 3.
In this article, we present a study on the levels of epidermal growth factor (EGF), its phosphorylated receptor (p-EGFR) and transforming growth factor-β1 (TGF-β1) in the sera of patients with hepatocellular carcinoma (HCC) and chronic hepatitis C (CHC) infection. The results reveal significant higher serum levels of EGF and TGF-β1 in patients with HCC compared to their level in patients with CHC infection and control subjects. The levels of p-EGFR in HCC and CHC patients show a highly significant difference between patients. Based on the best cutoff value of 914 pg/ml, EGF shows 63.3 % sensitivity and 87.5 % specificity for HCC patients where the area under the curve is 0.81. The p-EGFR shows sensitivity of 63.3 % and specificity of 100 % where the area under the curve is 0.87 for HCC patients based on the best cutoff value of 39 U/mg protein. The best cutoff value (370 pg/ml) for serum TGF-β1 displays sensitivity of 86.7 % and specificity of 100 %, where the area under the curve is 0.97 for HCC patients.
在本文中，我们研究了表皮生长因子（EGF）、其磷酸化受体（p-EGFR）和转化生长因子-β1（TGF-β1）在肝细胞癌（HCC）和慢性丙型肝炎（CHC）感染患者血清中的水平。结果显示，与 CHC 感染患者和对照组相比，HCC 患者的血清 EGF 和 TGF-β1 水平显著升高。HCC 和 CHC 患者的 p-EGFR 水平在患者之间存在显著差异。基于最佳截断值 914 pg/ml，EGF 对 HCC 患者的敏感性为 63.3%，特异性为 87.5%，曲线下面积为 0.81。p-EGFR 对 HCC 患者的敏感性为 63.3%，特异性为 100%，基于最佳截断值 39 U/mg 蛋白，曲线下面积为 0.87。血清 TGF-β1 的最佳截断值（370 pg/ml）对 HCC 患者的敏感性为 86.7%，特异性为 100%，曲线下面积为 0.97。
