辅酶 Q10 与男性不育：一项荟萃分析。
Coenzyme Q10 and male infertility: a meta-analysis.
机构信息
Andrology Laboratory, CIRH. Clínica Corachan. ANACER, Eguilaz, 14, bajos, 08017, Barcelona, Spain,
出版信息
J Assist Reprod Genet. 2013 Sep;30(9):1147-56. doi: 10.1007/s10815-013-0047-5. Epub 2013 Aug 3.
OBJECTIVE
To evaluate the effect of coenzyme Q10 treatments in male infertility, specifically in these parameters: live birth and pregnancy rates, CoQ10 seminal concentration, sperm concentration, and sperm motility.
MATERIALS AND METHODS
Systematic review and meta-analysis in male infertility patients with CoQ10 oral treatments. Three trials were included: 149 males in CoQ10 group and 147 males in placebo group.
RESULTS
None of the included trials provided any data regarding live births. The results of this meta-analysis show that supplementing infertile men with CoQ10 does not increase pregnancy rates. The analysis showed, among patients receiving CoQ10 treatment, a statistically significant increase in: CoQ10 seminal concentration (RR 49.55, 95 % CI 46.44 to 52.66, I(2) = 17 %), sperm concentration (RR 5.33, 95 % CI 4.18 to 6.47, I(2) = 58 %), and sperm motility (RR 4.50, 95 % CI 3.92 to 5.08, I(2) = 0 %)
CONCLUSION
There is no evidence in the literature that CoQ10 increases either live birth or pregnancy rates, but there is a global improvement in sperm parameters. Adequately powered, robust trials of individual and combination antioxidant therapies are required to guide clinical practice.
目的
评估辅酶 Q10 治疗男性不育症的效果，特别是在以下参数方面：活产率和妊娠率、CoQ10 精液浓度、精子浓度和精子活力。
材料和方法
对接受辅酶 Q10 口服治疗的男性不育症患者进行系统评价和荟萃分析。共纳入 3 项试验：辅酶 Q10 组 149 例，安慰剂组 147 例。
结果
纳入的试验均未提供任何关于活产的资料。本荟萃分析结果表明，补充辅酶 Q10 并不能提高妊娠率。分析显示，接受辅酶 Q10 治疗的患者中，CoQ10 精液浓度（RR 49.55，95%CI 46.44 至 52.66，I²=17%）、精子浓度（RR 5.33，95%CI 4.18 至 6.47，I²=58%）和精子活力（RR 4.50，95%CI 3.92 至 5.08，I²=0%）均有统计学显著增加。
结论
目前文献中尚无证据表明辅酶 Q10 能提高活产率或妊娠率，但能全面改善精子参数。需要进行设计合理、有力的个体和联合抗氧化治疗的临床试验，以指导临床实践。
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