Bouhadana David, Godin Pagé Marie-Hélène, Montjean Debbie, Bélanger Marie-Claire, Benkhalifa Moncef, Miron Pierre, Petrella Francis
Division of Urology, McGill University, Montreal, QC H4A 3J1, Canada.
Fertilys Fertility Centers, Laval, QC H7S 1Z5, Canada.
Antioxidants (Basel). 2025 Aug 19;14(8):1013. doi: 10.3390/antiox14081013.
Oxidative stress is a significant factor in male infertility, with increasing evidence evaluating the role of antioxidants in mitigating its detrimental effects on sperm function and quality. This review examines the mechanisms by which reactive oxygen species (ROS) impact male reproductive health. This article synthesizes the different mechanisms at play and highlights key clinical studies published in the literature that contribute to our understanding of antioxidants to treat male infertility. These studies suggest that supplementation with specific antioxidants may improve sperm parameters and increase fertility outcomes, although results vary depending on dosage, duration, and individual health conditions. Despite promising findings, there are inconsistencies across study methodologies and a lack of standardized treatment protocols, which underscore the need for more rigorous clinical trials. Antioxidant supplementation has the potential to serve as a supportive treatment for male infertility, but it should be approached cautiously and appropriately by carefully selecting patients who are deficient in the administered antioxidants. There is a need to better evaluate the long-term impact on reproductive outcomes and determine the optimal supplementation strategies and patient profiles that would benefit most from supplementation regimens.
氧化应激是男性不育的一个重要因素，越来越多的证据评估了抗氧化剂在减轻其对精子功能和质量的有害影响方面的作用。本综述探讨了活性氧（ROS）影响男性生殖健康的机制。本文综合了发挥作用的不同机制，并重点介绍了文献中发表的关键临床研究，这些研究有助于我们理解抗氧化剂治疗男性不育的作用。这些研究表明，补充特定的抗氧化剂可能改善精子参数并提高生育结果，尽管结果因剂量、持续时间和个体健康状况而异。尽管有令人鼓舞的发现，但研究方法存在不一致之处，且缺乏标准化的治疗方案，这突出表明需要进行更严格的临床试验。抗氧化剂补充剂有可能作为男性不育的辅助治疗方法，但应谨慎并适当地进行，通过仔细挑选体内所补充抗氧化剂缺乏的患者来实现。有必要更好地评估其对生殖结果的长期影响，并确定最能从补充方案中受益的最佳补充策略和患者特征。
