尼日利亚拉各斯大学教学医院2型糖尿病患者代谢综合征的患病率。

The prevalence of metabolic syndrome in persons with type 2 diabetes at the Lagos University Tteaching Hospital, Lagos, Nigeria.

作者信息

Udenze I C, Azinge E C, Arikawe A P, Egbuagha E U, Onyenekwu C, Ayodele O, Adizua U C

机构信息

Department of Clinical Pathology, Lagos University Teaching Hospital, Lagos state, Nigeria.

出版信息

West Afr J Med. 2013 Apr-Jun;32(2):126-32.

PMID:23913501

Abstract

BACKGROUND

Over the past decade, Lagos state has witnessed greater industrialization and increased economic prosperity. Lifestyle has become increasingly westernized, characterised by intake of excesscalories and physical inactivity. It is possible that these changes would lead to increases in the prevalence of metabolic syndrome and type 2 diabetes which are known cardiovascular risk factors. It became important therefore to study the prevalence of metabolic syndrome in type 2 diabetes in Lagos, Nigeria as at the present time and compare it with previous prevalence rates as well as rates from other centres as a way of assessing current cardiovascular risk burden in this population.

OBJECTIVES

This study is to determine the prevalence of metabolic syndrome in type 2 diabetes and to correlate the presence of microalbuminuria with glycaemic control.

METHODS

One hundred subjects with type 2 diabetes were selected by simple random sampling from patients attending The Diabetic Clinic at the Lagos University Teaching Hospital, Lagos, Nigeria.Age and sex matched controls were recruited from members of staff of the hospital.Clinical data was obtained by interviewing the participants. Anthropometric measurements were made and blood and urine specimens were collected for analysis. The World Health Organisation (WHO) criteria which is specified for the diagnosis of metabolic syndrome in the setting of type 2 diabetes was used to determine the prevalence of metabolic syndrome in this population.

RESULTS

Central obesity had the highest prevalence (79%) among persons with diabetes,followed by hypertension (69%), low HDL (50%), general obesity (40%), microalbuminuria (24%) and hypertriglyceridemia (10%). The prevalence of metabolic syndrome was 86%in this group. The commonest occurring metabolic syndrome component among patients with type 2 diabetes and metabolic syndrome was obesity (91.9%). There was a moderate positive correlation(r=0.52; p=0.01) between HbA1c values and microalbuminuria in persons with diabetes and the metabolic syndrome.

CONCLUSION

The prevalence of metabolic syndrome is very high among patients with type 2 diabetes in The Lagos University Teaching Hospital, Lagos, Nigeria.

摘要

背景

在过去十年中，拉各斯州经历了更大程度的工业化和经济繁荣。生活方式日益西化，其特点是热量摄入过多和缺乏身体活动。这些变化可能会导致代谢综合征和2型糖尿病的患病率上升，而这两种疾病都是已知的心血管危险因素。因此，研究目前尼日利亚拉各斯2型糖尿病患者中代谢综合征的患病率，并将其与先前的患病率以及其他中心的患病率进行比较，以此来评估该人群当前的心血管风险负担，就变得很重要。

目的

本研究旨在确定2型糖尿病患者中代谢综合征的患病率，并将微量白蛋白尿的存在与血糖控制情况相关联。

方法

通过简单随机抽样从尼日利亚拉各斯拉各斯大学教学医院糖尿病诊所就诊的患者中选取100名2型糖尿病患者。从医院工作人员中招募年龄和性别匹配的对照组。通过访谈参与者获取临床数据。进行人体测量，并采集血液和尿液样本进行分析。采用世界卫生组织（WHO）在2型糖尿病背景下诊断代谢综合征的标准来确定该人群中代谢综合征的患病率。

结果

在糖尿病患者中，中心性肥胖的患病率最高（79%），其次是高血压（69%）、低高密度脂蛋白（50%）、全身性肥胖（40%）、微量白蛋白尿（24%）和高甘油三酯血症（10%）。该组中代谢综合征的患病率为86%。2型糖尿病合并代谢综合征患者中最常见的代谢综合征组分是肥胖（91.9%）。糖尿病合并代谢综合征患者的糖化血红蛋白值与微量白蛋白尿之间存在中度正相关（r = 0.52；p = 0.01）。