Centre of Biotechnology, Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy.
Phytother Res. 2014 May;28(5):781-3. doi: 10.1002/ptr.5049. Epub 2013 Aug 5.
The anticancer action of gallotannins is a well-developed topic. We have demonstrated the in vivo antitumour activity of corilagin on Hep3B hepatoma using the xenograft athymic nude mice model. Here, we further report the potential sensitization of Hep3B hepatoma cells to cisplatin and doxorubicin by corilagin. Our results showed that corilagin is able to enhance the cytotoxicity of both cisplatin and doxorubicin on the Hep3B hepatoma cells. We speculate the possible use of corilagin in combination with low dosages of the anticancer chemotherapeutic standard drugs like cisplatin and doxorubicin, with the aim of obtaining an increment in the anticancer effect.
鞣花单宁的抗癌作用是一个研究得比较透彻的课题。我们已经通过荷瘤无胸腺裸鼠模型证实了柯里拉京对 Hep3B 肝癌的体内抗肿瘤活性。在这里，我们进一步报告了柯里拉京对 Hep3B 肝癌细胞对顺铂和阿霉素的潜在增敏作用。我们的结果表明，柯里拉京能够增强顺铂和阿霉素对 Hep3B 肝癌细胞的细胞毒性。我们推测，柯里拉京可能与低剂量的抗癌化疗标准药物如顺铂和阿霉素联合使用，以达到增强抗癌效果的目的。
