Endo G, Horiguchi S, Kiyota I
Department of Preventive Medicine and Environmental Health, Osaka City University Medical School, Japan.
J Appl Toxicol. 1990 Aug;10(4):235-8. doi: 10.1002/jat.2550100402.
The adverse effects of long-term exposure to lead dust on renal tubular functions were studied in 39 male and 7 female workers in a secondary lead refinery. Laboratory examinations showed low or moderate lead absorption levels. The N-acetyl-beta-D-glucosaminidase (NAG) activity in urine showed significant correlation with each of the lead exposure indices. NAG activity increased remarkably in lead workers with blood lead (PbB) above 80 micrograms 100g-1. Blood urea nitrogen (BUN) showed significant correlation with PbB and logarithmic urine delta-amino-levulinic acid (log(ALAU)), but not with urine lead (PbU) and logarithmic urine coproporphyrin (log(CPU)). All the other indices of renal function were almost within the normal range and showed no correlation with lead indices. This study suggests that moderate lead absorption may cause renal tubular impairment, and NAG can be one of the most sensitive indices for estimating renal dysfunction due to lead poisoning.
对一家二级铅冶炼厂的39名男性和7名女性工人进行了长期接触铅尘对肾小管功能的不良影响研究。实验室检查显示铅吸收水平低或中等。尿中N - 乙酰 - β - D - 氨基葡萄糖苷酶（NAG）活性与各铅暴露指标均呈显著相关。血铅（PbB）高于80微克/100克的铅作业工人NAG活性显著升高。血尿素氮（BUN）与PbB和尿δ - 氨基 - γ - 酮戊酸对数（log(ALAU)）显著相关，但与尿铅（PbU）和尿粪卟啉对数（log(CPU)）无关。所有其他肾功能指标几乎都在正常范围内，且与铅指标无关。本研究表明，中度铅吸收可能导致肾小管损害，NAG可作为评估铅中毒所致肾功能障碍最敏感的指标之一。
