Discovery Research, Dow AgroSciences , 9330 Zionsville Road, Indianapolis, Indiana 46268, USA.
J Nat Prod. 2013 Aug 23;76(8):1509-13. doi: 10.1021/np400232j. Epub 2013 Aug 5.
Phoslactomycins H (1) and I (2), two new members of the phoslactomycin class of chemistry, were isolated from Streptomyces sp. MLA1839 on the basis of their antifungal activities. Their structures were elucidated using extensive NMR spectroscopy and mass spectrometry. Phoslactomycin H (1) featured a rare and unprecedented N,N-dimethylamine substitution at C-4 and existed as a hydroxy acid rather than the more common lactone. Herein, we report the structure of these compounds and their biological activities.
磷霉素 H（1）和 I（2）是从 Streptomyces sp. MLA1839 中分离出来的两种新型磷霉素类化合物，具有抗真菌活性。它们的结构通过广泛的 NMR 光谱和质谱解析得到阐明。磷霉素 H（1）在 C-4 位具有罕见且前所未有的 N,N-二甲基胺取代，并且是羟基酸而不是更常见的内酯。本文报道了这些化合物的结构及其生物活性。
