磷雷霉素E作为烟曲霉IFO 5840中一种可诱导菌丝形态异常的代谢产物的鉴定。

Identification of phoslactomycin E as a metabolite inducing hyphal morphological abnormalities in Aspergillus fumigatus IFO 5840.

作者信息

Mizuhara Naoko, Usuki Yoshinosuke, Ogita Masaki, Fujita Ken-Ichi, Kuroda Manabu, Doe Matsumi, Iio Hideo, Tanaka Toshio

出版信息

J Antibiot (Tokyo). 2007 Dec;60(12):762-5. doi: 10.1038/ja.2007.101.

DOI:10.1038/ja.2007.101

Abstract

In our survey for antifungal compounds, a fermentation broth of Streptomyces sp. HA81-2 was found to inhibit the in vitro growth of Aspergillus fumigatus IFO 5840 accompanied by hyphal morphological abnormalities. One of the isolated antibiotics was identified as phoslactomycin E based on LC-MS and NMR spectral data. In a preliminary assay using the membrane fractions of A. fumigatus, phoslactomycin E was found to inhibit the activity of 1,3-beta glucan synthase.

摘要

在我们对抗真菌化合物的调查中，发现链霉菌属HA81-2的发酵液可抑制烟曲霉IFO 5840的体外生长，并伴有菌丝形态异常。根据液相色谱-质谱联用（LC-MS）和核磁共振（NMR）光谱数据，鉴定出其中一种分离出的抗生素为磷乳霉素E。在一项使用烟曲霉膜组分的初步试验中，发现磷乳霉素E可抑制1,3-β-葡聚糖合酶的活性。