新型磷酸酯类抗真菌抗生素磷霉素的研究。II. 磷霉素A至F的结构解析。
Studies on new phosphate ester antifungal antibiotics phoslactomycins. II. Structure elucidation of phoslactomycins A to F.
作者信息
Fushimi S, Furihata K, Seto H
机构信息
Institute of Applied Microbiology, University of Tokyo, Japan.
出版信息
J Antibiot (Tokyo). 1989 Jul;42(7):1026-36. doi: 10.7164/antibiotics.42.1026.
PMID:2753809
Abstract
Phoslactomycins A to F are new antifungal antibiotics produced by Streptomyces nigrescens SC-273. On the basis of physico-chemical properties and NMR studies, their structures have been determined as shown in Fig. 6. They are characterized by possessing alpha, beta-unsaturated delta-lactone, phosphate ester, conjugated diene and cyclohexane ring moieties. The structural difference between them is ascribed to a substituent bound to the cyclohexane ring.
摘要
磷乳霉素A至F是由暗黑链霉菌SC-273产生的新型抗真菌抗生素。根据物理化学性质和核磁共振研究，已确定它们的结构如图6所示。它们的特征在于具有α，β-不饱和δ-内酯、磷酸酯、共轭二烯和环己烷环部分。它们之间的结构差异归因于与环己烷环相连的一个取代基。
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