Smith M J, Ford-Hutchinson A W, Elliott P N
J Pharm Pharmacol. 1975 Jul;27(7):473-8. doi: 10.1111/j.2042-7158.1975.tb09487.x.
Acetylsalicylic acid (aspirin) and sodium salicylate are equally effective in reducing the swelling in the carrageenan-induced paw test and the accumulation of leucocytes into the inflammatory exudate produced by the subcutaneous implantation of polyvinyl sponges in the rat. Aspirin but not sodium salicylate caused a significant reduction in the potentiation of paw oedema found after the concurrent administration of carrageenan and arachidonic acid. Some implications of these findings are discussed.
乙酰水杨酸（阿司匹林）和水杨酸钠在减轻角叉菜胶诱发的爪部试验肿胀以及减少大鼠皮下植入聚乙烯海绵所产生的炎性渗出物中白细胞的积聚方面效果相当。阿司匹林而非水杨酸钠能显著减轻在同时给予角叉菜胶和花生四烯酸后发现的爪部水肿增强现象。文中讨论了这些发现的一些意义。
