双氯芬酸对大鼠角叉菜胶气囊渗出液中前列腺素生成的影响。

Effect of fenclofenac on prostaglandin production in carageenin air bleb exudates in rats.

作者信息

Atkinson D C, Leach E C

出版信息

Agents Actions. 1978 Apr;8(3):263-7. doi: 10.1007/BF01966613.

DOI:10.1007/BF01966613

Abstract

Employing a modified carrageenin air bleb technique in rats, the effect was studied of fenclofenac and standard drugs (acetylsalicylic acid, indomethacin and phenylbutazone) on prostaglandin production in inflammatory exudate. In common with the standard drugs, fenclofenac reduced exudate prostaglandin levels, being approximately equipotent with phenylbutazone in this respect. Also, an attempt was made to relate the effect of fenclofenac and standard drugs on prostaglandins to their acute anti-inflammatory activity as determined in a modified carrageenin paw oedema test in rats. Whilst acetylsalicylic acid and phenybutazone significantly inhibited oedema at doses producing 80% inhibition of prostaglandin production in air bleb exudate, fenclofenac and indomethacin did not. The overall results were considered to support the view expressed by other workers that the acute anti-inflammatory activity of acidic anti-inflammatory agents does not result solely, if at all, from inhibition of prostaglandin synthesis.

摘要

在大鼠中采用改良的角叉菜胶气疱技术，研究了芬氯酸及标准药物（阿司匹林、吲哚美辛和保泰松）对炎性渗出物中前列腺素生成的影响。与标准药物一样，芬氯酸降低了渗出物中前列腺素水平，在这方面与保泰松效力大致相当。此外，还尝试将芬氯酸和标准药物对前列腺素的作用与其在改良的大鼠角叉菜胶足爪水肿试验中所测定的急性抗炎活性联系起来。虽然阿司匹林和保泰松在产生80%抑制气疱渗出物中前列腺素生成的剂量下显著抑制了水肿，但芬氯酸和吲哚美辛却没有。总体结果被认为支持了其他研究人员所表达的观点，即酸性抗炎药的急性抗炎活性并非完全（如果有的话）源于对前列腺素合成的抑制。