Le Quesne P M, Fowler C J, Parkhouse N
Department of Neurological Studies, University College and Middlesex School of Medicine, London, United Kingdom.
J Neurol Neurosurg Psychiatry. 1990 Jul;53(7):558-63. doi: 10.1136/jnnp.53.7.558.
The results of applying a battery of peripheral nerve function tests in three groups of diabetics are reported. The tests examined the integrity of all the major subgroups of nerve fibres. The diabetics were grouped according to the clinical severity of their neuropathy: Group I--11 patients with long standing diabetes but clinically insignificant neuropathy, Group II--27 patients with mild neuropathy and Group III--23 patients with neuropathic foot lesions. As expected the incidence of abnormality of all functions increased from Group I to III, but within a group there was no clear pattern of differential involvement of different fibre types. The study has identified those tests that are suitable for detecting early neuropathy (warming and vibration perception thresholds and sensory nerve action potentials) and those which are likely to be useful in assessing deterioration or improvement (particularly vibration perception threshold), but since the different tests cannot be equally matched for sensitivity it is not possible to interpret the results in terms of the degree of pathological involvement of different fibre groups.
报告了在三组糖尿病患者中进行一系列周围神经功能测试的结果。这些测试检查了所有主要神经纤维亚组的完整性。糖尿病患者根据神经病变的临床严重程度分组：第一组——11例患有长期糖尿病但临床意义不明显的神经病变患者，第二组——27例患有轻度神经病变的患者，第三组——23例患有神经性足部病变的患者。正如预期的那样，所有功能异常的发生率从第一组到第三组逐渐增加，但在一组内，不同纤维类型的差异受累没有明确的模式。该研究确定了那些适合检测早期神经病变的测试（温热觉和振动觉阈值以及感觉神经动作电位）以及那些可能有助于评估病情恶化或改善的测试（特别是振动觉阈值），但由于不同测试在敏感性方面无法完全匹配，因此无法根据不同纤维组的病理受累程度来解释结果。
