Department of Pediatrics, Polish-American Institute of Pediatrics, Jagiellonian University Medical College, Krakow, Poland.
Clin Transl Allergy. 2013 Aug 1;3(1):25. doi: 10.1186/2045-7022-3-25.
Venom allergy is a rare but life-threatening disease and may have a considerable impact on the health-related quality of life (HRQoL) of patients, especially children. This paper presents development of the HRQoL scale for children and adolescents with Hymenoptera venom allergy (HVA).
The study sample consisted of 71 children, born between 1992 and 2000, who presented with a history of insect sting reaction when referred for consultation in the allergy center of Polish-American Children's Hospital, Krakow, Poland, during the period from 2000 to 2010. The initial pool of 60 items - divided into 6 domains - was prepared. The items with intercorrelations higher than 0.7 were removed from each domain and then principal component analysis was conducted for each domain separately, to provide a one-dimensional subscale for each domain. Reliability of the subscales was assessed using Cronbach alpha coefficient in terms of Classical Test Theory and with rho coefficient in terms of Item Response Theory. The multidimensionality of the scale was tested using multi-trait scaling.
Three to four items from each domain were subsequently selected to constitute six subscales. Rho coefficients for all the subscales reached 0.8, similar results were achieved with the Cronbach alpha coefficients. Multi-trait method showed that the majority of the items indicated stronger correlations with their own subscales than with other subscales, which proves that our constructed subscales measure different dimensions of HRQoL.
The presented scale comprises high validity and reliability subscales measuring six dimensions of HRQoL related to Hymenoptera venom allergy in children and adolescents. Such information may be useful in everyday clinical practice.
毒液过敏是一种罕见但危及生命的疾病，可能对患者（尤其是儿童）的健康相关生活质量（HRQoL）产生重大影响。本文介绍了用于评估膜翅目毒液过敏（HVA）儿童和青少年 HRQoL 的量表的开发。
研究样本包括 71 名儿童，他们于 2000 年至 2010 年期间在波兰裔美国儿童医院过敏中心就诊时，曾因昆虫叮咬反应就诊。最初的 60 项问卷条目分为 6 个领域。删除各领域中相关系数大于 0.7 的条目，然后对每个领域分别进行主成分分析，以提供每个领域的一维子量表。使用经典测试理论的 Cronbach alpha 系数和项目反应理论的 rho 系数评估子量表的可靠性。使用多特质标度检验量表的多维性。
从每个领域中选择了 3 到 4 个条目来构成六个子量表。所有子量表的 rho 系数均达到 0.8，Cronbach alpha 系数也取得了相似的结果。多特质方法表明，大多数条目与其自身子量表的相关性强于与其他子量表的相关性，这证明我们构建的子量表衡量了 HRQoL 的不同维度。
本文介绍的量表包括具有高度有效性和可靠性的子量表，用于评估儿童和青少年膜翅目毒液过敏相关的六个维度的 HRQoL。这些信息在日常临床实践中可能会很有用。
