University of Queensland Diamantina Institute, Translational Research Institute, 37 Kent Road, Princess Alexandra Hospital, Brisbane, Australia.
Mol Immunol. 2014 Jan;57(1):2-11. doi: 10.1016/j.molimm.2013.06.013. Epub 2013 Jul 31.
Ankylosing spondylitis (AS) is a chronic inflammatory arthritis that affects the spine and sacroiliac joints. It causes significant disability and is associated with a number of other features including peripheral arthritis, anterior uveitis, psoriasis and inflammatory bowel disease (IBD). Significant progress has been made in the genetics of AS have in the last five years, leading to new treatments in trial, and major leaps in understanding of the aetiopathogenesis of the disease.
强直性脊柱炎（AS）是一种慢性炎症性关节炎，影响脊柱和骶髂关节。它会导致严重的残疾，并与许多其他特征相关，包括外周关节炎、前葡萄膜炎、银屑病和炎症性肠病（IBD）。在过去五年中，AS 的遗传学研究取得了重大进展，导致了新的治疗方法进入临床试验，并在疾病的发病机制方面取得了重大飞跃。
