Biological and Chemical Research Institute, Universidad Michoacana de San Nicolás de Hidalgo, Morelia, Michoacán 58060, Mexico.
Centro de Investigación y de Estudios Avanzados (CINVESTAV) Unidad Querétaro, Libramiento Norponiente 2000, Querétaro, Qro. 76230, Mexico.
Colloids Surf B Biointerfaces. 2013 Nov 1;111:741-6. doi: 10.1016/j.colsurfb.2013.07.003. Epub 2013 Jul 10.
The relationship between electrical conductivity, structure and antibacterial properties of chitosan-silver nanoparticles (CS/AgnP) biocomposites has been analyzed. To test the film's antimicrobial activity, Gram-positive and Gram-negative bacteria were studied. The interactions between silver nanoparticles with chitosan suggest the formation of silver ions which plays a major role in nanocomposite's bactericidal potency. In CS/AgnP biocomposites, the bactericide effectiveness increases by increasing AgnP concentrations up to 3 wt%, which is close to the electrical percolation threshold of ca. 3 wt%. As the AgnP concentration increases above this threshold, the bactericidal potency is greatly diminished. The elucidated correlation between electrical conductivity and antibacterial activity could be useful in the design of other nanocomposites that involve polymeric-based matrices.
已经分析了壳聚糖-银纳米粒子（CS/AgnP）生物复合材料的电导率、结构和抗菌性能之间的关系。为了测试薄膜的抗菌活性，研究了革兰氏阳性菌和革兰氏阴性菌。银纳米粒子与壳聚糖之间的相互作用表明形成了银离子，这在纳米复合材料的杀菌效力中起主要作用。在 CS/AgnP 生物复合材料中，随着 AgnP 浓度增加到 3wt%，杀菌效果显著提高，这接近于约 3wt%的电渗流阈值。当 AgnP 浓度超过这个阈值时，杀菌效力大大降低。所阐明的电导率与抗菌活性之间的相关性可能有助于设计涉及基于聚合物的基质的其他纳米复合材料。
