Song Xinyang, Qian Youcun
The Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences/Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Cell Signal. 2013 Dec;25(12):2335-47. doi: 10.1016/j.cellsig.2013.07.021. Epub 2013 Jul 31.
Inflammation is the immediate protective response of the body to pathogen invasions, allergen challenges, chemical exposures or physical injuries. Acute inflammation usually accompanies with transient infiltration of leukocytes, removal of danger signals and eventually tissue repair, while persistent and uncontrolled inflammation becomes a major stimulator in the progression of many chronic diseases in human, including autoimmune diseases, metabolic disorders and cancer. Interleukin (IL)-17 family is a recent classified subset of cytokines, playing critical roles in both acute and chronic inflammatory responses. In this review, we will summarize recent progresses on the signalings of this family cytokines and their impacts on the inflammatory responses or disorders.
炎症是机体对病原体入侵、过敏原刺激、化学物质暴露或物理损伤的即时保护性反应。急性炎症通常伴随着白细胞的短暂浸润、危险信号的清除以及最终的组织修复，而持续且不受控制的炎症则成为人类许多慢性疾病进展的主要刺激因素，包括自身免疫性疾病、代谢紊乱和癌症。白细胞介素（IL）-17家族是最近分类的细胞因子亚群，在急性和慢性炎症反应中均发挥关键作用。在本综述中，我们将总结该家族细胞因子信号传导的最新进展及其对炎症反应或疾病的影响。
