He Jun, Zhang Xinyu, Ge Zhili, Shi Jingjing, Guo Shuwen, Chen Jun
China Ordnance Industry Group-machine-environment Key Laboratory, Institute for Hygiene of Ordnance Industry, NO.12 Zhangba East Road, Yanta District, Xi'an, 710065, Shaanxi, China.
Sanhang Institute for Brain Science and Technology, Northwestern Polytechnical University, Xi'an, 710129, Shaanxi, China.
Sci Rep. 2025 Mar 5;15(1):7759. doi: 10.1038/s41598-025-90396-3.
Whole-body cryotherapy (WBC) is increasingly being studied and used in various populations, mainly focusing on improving the body's regenerative capacity. More comprehensive summaries of anti-inflammatory responses are needed. To systemically assess the effect of WBC on the inflammatory response in humans based on randomized controlled trials (RCTs). Articles about RCTs accessing the effects of whole-body cryotherapy on the levels of inflammatory factors in humans published until August 1, 2024 had been searched in PubMed, Web of Science, Embase and Cochrane library databases. The general information of the included articles and exposure mode, the types and levels of inflammatory factors in serum were extracted. The PEDro scale was used to assess the risk of bias, and the GRADE scale was used to assess the level of certainty of evidence. RevMan 5.4 software were used to conduct the meta-analysis. A total of 11 RCTs in 11 articles were included, and the total sample size was 274. The level of IL-1β in serum of people exposed to WBC was lower than that in control group (SMD value was - 2.08pg/mL, P < 0.05), and athletes exposed to WBC were more likely to benefit from this. The level of IL-10 in serum of people exposed to WBC was higher than that in control group ( SMD value was 0.78 pg/mL, P < 0.05), and obese people exposed to WBC were more likely to benefit from this than athletes. WBC effectively reduces inflammation by lowering IL-1β and increasing IL-10 levels, offering significant benefits for athletes and obese individuals.
全身冷冻疗法（WBC）越来越多地在各类人群中得到研究和应用，主要聚焦于提高身体的再生能力。目前需要更全面地总结其抗炎反应。基于随机对照试验（RCT）系统评估全身冷冻疗法对人体炎症反应的影响。检索了截至2024年8月1日在PubMed、科学网、Embase和Cochrane图书馆数据库中发表的关于全身冷冻疗法对人体炎症因子水平影响的随机对照试验文章。提取了纳入文章的一般信息、暴露模式、血清中炎症因子的类型和水平。采用PEDro量表评估偏倚风险，采用GRADE量表评估证据的确定性水平。使用RevMan 5.4软件进行荟萃分析。共纳入11篇文章中的11项随机对照试验，总样本量为274。接受全身冷冻疗法的人群血清中IL-1β水平低于对照组（标准化均值差（SMD）值为-2.08pg/mL，P<0.05），接受全身冷冻疗法的运动员更可能从中受益。接受全身冷冻疗法的人群血清中IL-10水平高于对照组（SMD值为0.78pg/mL，P<0.05），接受全身冷冻疗法的肥胖者比运动员更可能从中受益。全身冷冻疗法通过降低IL-1β水平和提高IL-10水平有效减轻炎症，对运动员和肥胖个体具有显著益处。
