Haruta T, Kuroki S, Okura K, Kobayashi Y
Department of Pediatrics, Kobe City General Hospital.
Jpn J Antibiot. 1990 May;43(5):872-6.
We studied clinical effects of norfloxacin (NFLX, AM-715) tablets. The results we found are summarized as follows: 1. Ten patients with 5 diseases were medicated with 7.0-14.8 mg/kg of the drug 3 times daily for 6-8 days. They consisted of one-each with tonsillitis, pharyngitis, bronchitis, 4 with Campylobacter enteritis, 3 with other enteritis. Clinical responses to the treatment were excellent in 8, good in 1 and fair in 1, with an efficacy rate of 90%. Bacteriologically, of 9 isolates for which changes in populations were followed, 6 were eradicated and 3 remained unchanged, with an eradication rate of 66.7%. 2. No. adverse reactions nor abnormal laboratory test values attributable to the drug were observed. 3. These results suggest that this new quinolone drug may be useful, against bacterial infections in children 6 years and older.
我们研究了诺氟沙星（NFLX，AM - 715）片剂的临床效果。我们发现的结果总结如下：1. 10名患有5种疾病的患者，以7.0 - 14.8毫克/千克的剂量每日服药3次，持续6 - 8天。其中扁桃体炎、咽炎、支气管炎各1例，空肠弯曲菌肠炎4例，其他肠炎3例。治疗的临床反应为8例优，1例良，1例中，有效率为90%。在细菌学方面，对9株追踪菌群变化的分离菌而言，6株被根除，3株无变化，根除率为66.7%。2. 未观察到与该药物相关的不良反应或实验室检查值异常。3. 这些结果表明，这种新型喹诺酮类药物可能对6岁及以上儿童的细菌感染有效。
