Morita H, Tomoda T, Araki K, Kurashige T, Nishibayashi Y, Matsumoto K, Zushi N
Department of Pediatrics, Kochi Medical School.
Jpn J Antibiot. 1990 May;43(5):884-9.
We have evaluated norfloxacin (NFLX) tablets for therapeutic effectiveness and safety in children. The results are summarized as follows. 1. A clinical study was performed on 14 children with infections, including 12 with urinary tract infections and 2 with acute bronchitis. Doses ranging from 1.7 to 5.4 mg/kg body weight were given b.i.d. or t.i.d.. Lengths of treatment ranged from 3 to 15 days. The therapeutic responses were considered "excellent" in 8 and "good" in 5, with an efficacy rate of 93%. 2. Side effects were observed in 2 cases, one with light-headed feeling and one with vomiting. In clinical laboratory tests, eosinophilia was found in 2 cases and GOT was slightly elevated in 1 case. It has been concluded that NFLX is a usable drug for the treatment of bacterial infections in children.
我们评估了诺氟沙星（NFLX）片剂对儿童的治疗效果和安全性。结果总结如下。1. 对14名感染儿童进行了一项临床研究，其中包括12名尿路感染患儿和2名急性支气管炎患儿。给予的剂量为1.7至5.4毫克/千克体重，每日两次或三次。治疗时间为3至15天。治疗反应被认为“优秀”的有8例，“良好”的有5例，有效率为93%。2. 观察到2例副作用，1例有头晕感，1例有呕吐。在临床实验室检查中，2例发现嗜酸性粒细胞增多，1例谷草转氨酶略有升高。得出的结论是，诺氟沙星是治疗儿童细菌感染的可用药物。
