一种新型人类冠状病毒：中东呼吸综合征冠状病毒。
A novel human coronavirus: Middle East respiratory syndrome human coronavirus.
机构信息
Biotech Center for Viral Disease Emergency, Key Laboratory of Medical Virology and Viral Diseases Prevention and Control, Ministry of Health, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
出版信息
Sci China Life Sci. 2013 Aug;56(8):683-7. doi: 10.1007/s11427-013-4519-8. Epub 2013 Aug 7.
Abstract
In 2012, a novel coronavirus, initially named as human coronavirus EMC (HCoV-EMC) but recently renamed as Middle East respiratory syndrome human coronavirus (MERS-CoV), was identified in patients who suffered severe acute respiratory infection and subsequent renal failure that resulted in death. Ongoing epidemiological investigations together with retrospective studies have found 61 laboratory-confirmed cases of infection with this novel coronavirus, including 34 deaths to date. This novel coronavirus is culturable and two complete genome sequences are now available. Furthermore, molecular detection and indirect immunofluorescence assay have been developed. The present paper summarises the limited recent advances of this novel human coronavirus, including its discovery, genomic characterisation and detection.
摘要
2012 年，一种新型冠状病毒，最初被命名为人冠状病毒 EMC（HCoV-EMC），但最近更名为中东呼吸综合征冠状病毒（MERS-CoV），在患有严重急性呼吸道感染和随后导致死亡的肾衰竭的患者中被发现。正在进行的流行病学调查和回顾性研究发现了 61 例实验室确诊的新型冠状病毒感染病例，其中 34 例死亡。这种新型冠状病毒可培养，现在已有两个完整的基因组序列。此外，还开发了分子检测和间接免疫荧光检测。本文总结了这种新型人类冠状病毒的最新进展，包括其发现、基因组特征和检测。
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2
[Molecular detection assays for 2012 identified novel human coronavirus (HCoV) and probe modification with locked nucleic acid (LNA)].2012年的分子检测分析鉴定出新型人类冠状病毒（HCoV）以及用锁核酸（LNA）进行的探针修饰。
Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2012 Dec;26(6):401-4.
3
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