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Control of P2X3 channel function by metabotropic P2Y2 utp receptors in primary sensory neurons.初级感觉神经元中代谢型 P2Y2 UTP 受体对 P2X3 通道功能的控制。
Mol Pharmacol. 2013 Mar;83(3):640-7. doi: 10.1124/mol.112.082099. Epub 2012 Dec 18.
2
P2Y purinergic receptors: new targets for analgesic and antimigraine drugs.P2Y 嘌呤能受体：镇痛和抗偏头痛药物的新靶点。
Biochem Pharmacol. 2013 Feb 15;85(4):466-77. doi: 10.1016/j.bcp.2012.10.027. Epub 2012 Nov 9.
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Pathophysiology of astroglial purinergic signalling.星形胶质细胞嘌呤能信号转导的病理生理学。
Purinergic Signal. 2012 Sep;8(3):629-57. doi: 10.1007/s11302-012-9300-0. Epub 2012 May 1.
4
ATP signaling is deficient in cultured Pannexin1-null mouse astrocytes.培养的 Pannexin1 基因敲除小鼠星形胶质细胞中存在 ATP 信号转导缺陷。
Glia. 2012 Jul;60(7):1106-16. doi: 10.1002/glia.22338. Epub 2012 Apr 12.
5
Satellite glial cell P2Y12 receptor in the trigeminal ganglion is involved in lingual neuropathic pain mechanisms in rats.三叉神经节卫星胶质细胞 P2Y12 受体参与大鼠舌神经病理性疼痛机制。
Mol Pain. 2012 Mar 30;8:23. doi: 10.1186/1744-8069-8-23.
6
Genetically determined P2X7 receptor pore formation regulates variability in chronic pain sensitivity.遗传决定的 P2X7 受体孔形成调节慢性疼痛敏感性的可变性。
Nat Med. 2012 Mar 25;18(4):595-9. doi: 10.1038/nm.2710.
7
P2X7 receptors in satellite glial cells mediate high functional expression of P2X3 receptors in immature dorsal root ganglion neurons.卫星胶质细胞中的 P2X7 受体介导未成熟背根神经节神经元中 P2X3 受体的高功能表达。
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The participation of plasma membrane hemichannels to purinergic signaling.质膜半通道在嘌呤能信号传导中的作用。
Biochim Biophys Acta. 2013 Jan;1828(1):79-93. doi: 10.1016/j.bbamem.2012.01.002. Epub 2012 Jan 12.
9
Activation of satellite glial cells in lumbar dorsal root ganglia contributes to neuropathic pain after spinal nerve ligation.卫星胶质细胞在腰椎背根神经节中的激活有助于脊神经结扎后的神经病理性疼痛。
Brain Res. 2012 Jan 3;1427:65-77. doi: 10.1016/j.brainres.2011.10.016. Epub 2011 Oct 14.
10
Purinergic signalling: from normal behaviour to pathological brain function.嘌呤能信号转导：从正常行为到病理性脑功能。
Prog Neurobiol. 2011 Oct;95(2):229-74. doi: 10.1016/j.pneurobio.2011.08.006. Epub 2011 Sep 1.

感觉神经节中神经元胞体与卫星胶质细胞之间的通讯。

Communication between neuronal somata and satellite glial cells in sensory ganglia.

机构信息

Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, Texas 77555-1069, USA.

出版信息

Glia. 2013 Oct;61(10):1571-81. doi: 10.1002/glia.22541. Epub 2013 Aug 5.

DOI:10.1002/glia.22541
PMID:23918214
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3758405/
Abstract

Studies of the structural organization and functions of the cell body of a neuron (soma) and its surrounding satellite glial cells (SGCs) in sensory ganglia have led to the realization that SGCs actively participate in the information processing of sensory signals from afferent terminals to the spinal cord. SGCs use a variety ways to communicate with each other and with their enwrapped soma. Changes in this communication under injurious conditions often lead to abnormal pain conditions. "What are the mechanisms underlying the neuronal soma and SGC communication in sensory ganglia?" and "how do tissue or nerve injuries affect the communication?" are the main questions addressed in this review.

摘要

对感觉神经节中神经元（胞体）及其周围卫星胶质细胞（SGC）的结构组织和功能的研究，使人们认识到 SGC 积极参与从传入末梢到脊髓的感觉信号的信息处理。SGC 利用多种方式相互交流，并与它们包裹的胞体进行交流。在损伤条件下，这种通讯的变化常常导致异常的疼痛状况。“感觉神经节中神经元胞体和 SGC 通讯的机制是什么？”以及“组织或神经损伤如何影响通讯？”是本综述中主要探讨的问题。