College of Pharmacy and Division of Life & Pharmaceutical Sciences, Ewha Womans University, 52 Ewhayeodae-gil, Seodaemun-gu, Seoul, 120-750, Korea.
Arch Pharm Res. 2013 Oct;36(10):1238-43. doi: 10.1007/s12272-013-0220-5. Epub 2013 Aug 6.
Adolescence is critical in the habituation of diverse lifestyles and is a base for future physical well-being. Although gastrointestinal disorders are frequently reported in adolescents, studies related to GI drug use or related factors in Korean adolescents are rare. Thus, this study examined Korean adolescents for the use of GI drugs for abdominal symptoms and analyzed the associated factors. This cross-sectional study was done with a total of 2,416 students who completed a given questionnaire. The health-related questions included GI medication intake, smoking, alcohol, caffeine, regular exercise, self-cognitive health level, GI symptom, non-steroidal anti-inflammatory drugs (NSAIDs) intake, and sleep problems. In questions about GI medication intake, drugs included digestives and antacids. And the intake of GI drugs more than once during the past 1 month was regarded as taking GI drugs. The sociodemographic questions included age, gender, grade, number of close friends, extracurricular activities, and school performance. The overall prevalence for taking GI drugs, including antacids and digestives, was 17.4 %. When students taking GI drugs were compared with those not taking GI drugs, the former group showed higher rates of girls (P < 0.001) and participants in extracurricular activities (P < 0.05) than the latter group. Factors including alcohol, caffeine, self-cognitive health levels, and GI symptoms showed statistical significance with the rate of GI drug intake. The rate of GI drug intake in NSAID users was 2.7 times higher than that in non-users (P < 0.001). The prevalence rate of every sleep problem was higher in students taking GI medications except snoring, witnessed apnea, and teeth grinding. From the multiple regression, it was found that gender (female), extracurricular activities, alcohol intake, self-cognitive health levels, NSAIDs intake, and nightmares were related factors to GI drug intake. Based on the results, it was conclude that encouragement to build healthy lifestyle habits in adolescents is very important for their academic performances and health status in adulthood.
青春期是养成多样化生活方式的关键时期，也是未来身体健康的基础。尽管青少年常报告胃肠道疾病，但有关韩国青少年 GI 药物使用或相关因素的研究却很少。因此，本研究调查了韩国青少年因腹部症状而使用 GI 药物的情况，并分析了相关因素。这项横断面研究共纳入了 2416 名完成特定问卷的学生。与健康相关的问题包括 GI 药物摄入、吸烟、饮酒、咖啡因、规律运动、自我认知健康水平、胃肠道症状、非甾体抗炎药（NSAIDs）摄入和睡眠问题。在关于 GI 药物摄入的问题中，药物包括助消化药和抗酸药。在过去 1 个月内，GI 药物的摄入量超过 1 次被视为服用 GI 药物。社会人口学问题包括年龄、性别、年级、亲密朋友数量、课外活动和学业成绩。服用 GI 药物（包括抗酸药和助消化药）的总体流行率为 17.4%。与未服用 GI 药物的学生相比，服用 GI 药物的学生中女生比例较高（P<0.001），参加课外活动的比例较高（P<0.05）。包括饮酒、咖啡因、自我认知健康水平和胃肠道症状在内的因素与 GI 药物摄入率具有统计学意义。与非使用者相比，NSAID 使用者的 GI 药物使用率高 2.7 倍（P<0.001）。除打鼾、 witnessed apnea 和磨牙外，服用 GI 药物的学生出现每种睡眠问题的比率都较高。多元回归分析发现，性别（女性）、课外活动、饮酒、自我认知健康水平、NSAIDs 摄入和梦魇是与 GI 药物摄入相关的因素。基于这些结果，可以得出结论，鼓励青少年养成健康的生活方式习惯对于他们的学业成绩和成年后的健康状况非常重要。
