类固醇溃疡：有什么新消息吗？
Steroid ulcers: Any news?
作者信息
Guslandi Mario
机构信息
Mario Guslandi, Gastroenterology Unit, S.Raffaele Hospital, Milan 20132, Italy.
出版信息
World J Gastrointest Pharmacol Ther. 2013 Aug 6;4(3):39-40. doi: 10.4292/wjgpt.v4.i3.39.
Abstract
Steroid ulcers, although a common feature in experimental studies, seldom develop in clinical practice, as observed by the meta-analyses carried out in the 90s. Corticosteroids alone become ulcerogenic only if treatment lasts longer than one month and the total administered dose exceeds 1000 mg. On the other hand concomitant intake of non-steroidal anti-inflammatory drugs results in a synergistic, highly damaging effect on the gastroduodenal mucosa. Thus, despite the survival of the steroid ulcer myth in the medical culture, pharmacological protection against steroid-induced peptic ulcers is a rare necessity while the best prophylactic strategy still remains to be determined.
摘要
正如90年代进行的荟萃分析所观察到的那样，类固醇溃疡虽然在实验研究中是常见特征，但在临床实践中很少发生。仅当治疗持续超过一个月且总给药剂量超过1000毫克时，单独使用皮质类固醇才会产生致溃疡作用。另一方面，同时服用非甾体抗炎药会对胃十二指肠黏膜产生协同的、高度破坏性的影响。因此，尽管类固醇溃疡的说法在医学文化中仍然存在，但针对类固醇诱导的消化性溃疡的药物保护很少有必要，而最佳预防策略仍有待确定。
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