Pinho Eva, Grootveld Martin, Soares Graça, Henriques Mariana
Institute of Biotechnology and Bioengineering, University of Minho , Campus Gualtar, Braga , Portugal .
Crit Rev Biotechnol. 2014 Dec;34(4):328-37. doi: 10.3109/07388551.2013.794413. Epub 2013 Aug 6.
Optimal wound dressings should be capable of mechanical wound protection and also facilitate the healing process via maintenance of suitable environmental conditions and the controlled delivery of bioactive molecules. Hydrogels present suitable properties for wound-dressing applications such as good biocompatibility, together with a high water content, the latter of which is important for the maintenance of a moist environment and ready removal from the wound with a minimal level of associated pain. However, their properties as drug delivery systems can be improved by the use of cyclodextrins as cross-linking agents. Cyclodextrins have been extensively used as "carriers" on food, textile, cosmetic and, most especially, in the pharmaceutical industry in view of their powerful complexation abilities and biocompatibilities, together with further desirable characteristics. The conjugation of cyclodextrins with hydrogels may allow the achievement of an optimal wound-dressing material, because the hydrogel component will maintain the moist environment required for the healing process, and the cyclodextrin moiety has the ability to protect and modulate the release of bioactive molecules. Therefore, this review aims to gather information regarding cyclodextrin-based hydrogels for possible wound-dressing applications.
理想的伤口敷料应具备机械性伤口保护功能，还应通过维持适宜的环境条件以及控制生物活性分子的释放来促进愈合过程。水凝胶具有适合伤口敷料应用的特性，如良好的生物相容性以及高含水量，后者对于维持湿润环境和在最小程度的相关疼痛下从伤口轻松移除至关重要。然而，通过使用环糊精作为交联剂可以改善它们作为药物递送系统的性能。鉴于环糊精强大的络合能力、生物相容性以及其他理想特性，它们已在食品、纺织、化妆品行业，尤其是制药行业中广泛用作“载体”。环糊精与水凝胶的结合可能会产生一种理想的伤口敷料材料，因为水凝胶成分将维持愈合过程所需的湿润环境，而环糊精部分能够保护和调节生物活性分子的释放。因此，本综述旨在收集有关基于环糊精的水凝胶在伤口敷料应用方面的信息。
