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生物活性水凝胶在创伤愈合和药物输送系统中的应用研究进展

Insight Into Bioactive Hydrogels for Wound Healing and Drug Delivery Systems.

机构信息

School of Pharmacy, Health Science Center, Xi\'an Jiaotong University, Xi'an 710061, China.

Department of Pharmacy, Shenzhen Baoan Authentic TCM Therapy Hospital, Shenzhen 518101, China.

出版信息

Curr Med Chem. 2021;28(42):8692-8710. doi: 10.2174/0929867328666210405125348.

Abstract

Hydrogels are hydrophilic but water-soluble polymer systems with a three-dimensional network structure. They can absorb large amounts of water and maintain their shape and remain soft. The high-moisturizing properties, good biocompatibility, and controlled biodegradability of hydrogels have allowed them to be widely used in wound dressing, tissue engineering, controlled drug delivery systems, and other fields. This article reviews the most widely used antibacterial gel dressings for wound healing in recent years and focuses on the application of an environmentally responsive intelligent hydrogel delivery system. Finally, the development prospects and challenges of hydrogel wound dressings are forecasted.

摘要

水凝胶是一种亲水性但可溶于水的聚合物体系,具有三维网络结构。它们可以吸收大量的水分并保持其形状和柔软度。水凝胶具有高保湿性、良好的生物相容性和可控的生物降解性,因此被广泛应用于伤口敷料、组织工程、控释药物输送系统等领域。本文综述了近年来用于伤口愈合的最广泛使用的抗菌水凝胶敷料,并重点介绍了环境响应性智能水凝胶输送系统的应用。最后,预测了水凝胶伤口敷料的发展前景和挑战。

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