Centro de Física, Universidade do Minho, 4710-057, Braga, Portugal.
Grup de Biotecnologia Molecular i Industrial, Department of Chemical Engineering, Universitat Politècnica de Catalunya, Terrassa, Spain.
Curr Med Chem. 2018;25(41):5782-5797. doi: 10.2174/0929867324666170920161246.
Composed in a large extent of water and due to their nonadhesiveness, hydrogels found their way to the wound dressing market as materials that provide a moisture environment for healing while being comfortable to the patient. Hydrogels' exploitation is constantly increasing after evidences of their even broader therapeutic potential due to resemblance to dermal tissue and ability to induce partial skin regeneration. The innovation in advanced wound care is further directed to the development of so-called active dressings, where hydrogels are combined with components that enhance the primary purpose of providing a beneficial environment for wound healing.
The objective of this review is to concisely describe the relevance of hydrogel dressings as platforms for delivery of active molecules for improved management of difficult- to-treat wounds. The emphasis is on the most recent advances in development of stimuli- responsive hydrogels, which allow for control over wound healing efficiency in response to different external modalities. Novel strategies for monitoring of the wound status and healing progress based on incorporation of sensor molecules into the hydrogel platforms are also discussed.
水凝胶在很大程度上由水组成，由于其不粘性，它们作为为愈合提供湿润环境的材料进入伤口敷料市场，同时也让患者感到舒适。由于水凝胶类似于真皮组织并具有诱导部分皮肤再生的能力，其更广泛的治疗潜力的证据不断增加，其应用也在不断增加。先进伤口护理的创新进一步指向所谓的活性敷料的发展，其中水凝胶与增强提供有益伤口愈合环境的主要目的的成分结合。
本综述的目的是简要描述水凝胶敷料作为传递活性分子的平台的相关性，以改善治疗困难伤口的效果。重点介绍了刺激响应水凝胶的最新进展，这些进展可以根据不同的外部方式控制伤口愈合效率。还讨论了基于将传感器分子掺入水凝胶平台来监测伤口状况和愈合进展的新策略。
