Smutney Chad C, Grant Marshall, Kinsey P Spencer
MannKind Corp, One Casper St, Danbury CT 06810, USA.
Ther Deliv. 2013 Aug;4(8):939-49. doi: 10.4155/tde.13.77.
The use of orally inhaled dry powder technologies is one way of delivering medicines to the lung for treating local conditions or for achieving systemic effect. These involve dry powder formulations containing an active pharmaceutical ingredient together with inhaler devices. These powder/device systems enable patients to inhale and aerosolize the medicine into suitably sized particles that deposit in the lung. Several inhaler centric aspects of these delivery systems are presented and discussed in context of new product development. Case examples are provided to highlight several inhaler aspects and to guide development of powder/inhaler systems.
口服吸入干粉技术的应用是将药物输送至肺部以治疗局部病症或实现全身效应的一种方式。这些技术涉及含有活性药物成分的干粉制剂以及吸入装置。这些粉末/装置系统使患者能够吸入药物并将其雾化成大小合适的颗粒，从而沉积在肺部。本文结合新产品开发，介绍并讨论了这些给药系统中与吸入器相关的几个方面。文中提供了案例，以突出吸入器的几个方面，并指导粉末/吸入器系统的开发。
