Zhang Q, Wu Z, Feng Y, Shi J
Renji Hospital, Shanghai Second Medical University.
J Tradit Chin Med. 1990 Jun;10(2):132-5.
Determinations of plasma levels of sexual hormones in 43 male patients of chronic renal failure showed that the content of testosterone (T) decreased markedly, while estradiol (E2) and E2/T ratio were obviously higher than in normal subjects, with no significant correlation between the levels of these sexual hormones and renal function. According to syndrome-differentiation of TCM, 17 of the 43 cases belonged to deficiency of Kidney-yang, and the other 26 cases deficiency of Kidney-yin. In the patients with deficiency of Kidney-yang, the E2 level was not increased, but the T content decreased to make the E2/T ratio apparently elevated; whereas in the patients with deficiency of Kidney-yin, both E2 and E2/T were elevated. The level of E2 in deficiency of Kidney-yin was markedly higher than that in deficiency of Kidney-yang. The results indicated that patients of chronic renal failure of the type of deficiency of Kidney-yang differed in syndrome as well as in levels of the sexual hormones from the type of deficiency of Kidney-yin; however, the sexual hormones were not correlated with the renal functions in the two types of patients.
对43例慢性肾衰竭男性患者的性激素血浆水平测定结果显示，睾酮（T）含量显著降低，而雌二醇（E2）及E2/T比值明显高于正常受试者，这些性激素水平与肾功能之间无显著相关性。根据中医辨证，43例患者中17例属肾阳虚，26例属肾阴虚。肾阳虚患者中，E2水平未升高，但T含量降低，使E2/T比值明显升高；而肾阴虚患者中，E2及E2/T均升高。肾阴虚患者的E2水平明显高于肾阳虚患者。结果表明，肾阳虚型慢性肾衰竭患者与肾阴虚型患者在证候及性激素水平方面存在差异；然而，两类患者的性激素与肾功能均无相关性。
