Yeates Todd O, Jorda Julien, Bobik Thomas A
Department of Chemistry and Biochemistry, University of California, Los Angeles, Calif. 90095-1569, USA.
J Mol Microbiol Biotechnol. 2013;23(4-5):290-9. doi: 10.1159/000351347. Epub 2013 Aug 5.
Bacterial microcompartments are large proteinaceous structures that act as metabolic organelles in many bacterial cells. A shell or capsid, which is composed of a few thousand protein subunits, surrounds a series of sequentially acting enzymes and controls the diffusion of substrates and products into and out of the lumen. The carboxysome and the propanediol utilization microcompartment represent two well-studied systems among seven or more distinct types that can be delineated presently. Recent structural studies have highlighted a number of sophisticated mechanisms that underlie the function of bacterial microcompartment shell proteins. This review updates our understanding of bacterial microcompartment shells, how they are assembled, and how they carry out their functions in molecular transport and enzyme organization.
细菌微区室是许多细菌细胞中作为代谢细胞器的大型蛋白质结构。由数千个蛋白质亚基组成的外壳或衣壳围绕着一系列顺序作用的酶，并控制底物和产物进出腔室的扩散。羧酶体和1,2 - 丙二醇利用微区室是目前可以划分出的七种或更多不同类型中两个研究充分的系统。最近的结构研究突出了一些作为细菌微区室外壳蛋白功能基础的复杂机制。本综述更新了我们对细菌微区室外壳、它们如何组装以及它们如何在分子运输和酶组织中发挥功能的理解。
