MabCent-SFI, University of Tromsø, Breivika, N-9037, Tromsø, Norway.
Mar Drugs. 2013 Aug 5;11(8):2769-84. doi: 10.3390/md11082769.
Three known bromophenols, 2,3-dibromo-4,5-dihydroxybenzylaldehyde (1), 2,2',3-tribromo-3',4,4',5-tetrahydroxy-6'-hydroxymethyldiphenylmethane (2) and bis(2, 3-dibromo-4,5-dihydroxylbenzyl) ether (3), and one new one, 5,5″-oxybis(methylene)bis (3-bromo-4-(2',3'-dibromo-4',5'-dihydroxylbenzyl)benzene-1,2-diol) (4), were isolated from an extract of the red alga, Vertebrata lanosa. The antioxidant activity of these four bromophenols was examined using one biochemical and two cellular assays: Oxygen Radical Absorbance Capacity (ORAC), Cellular Antioxidant Activity (CAA) and Cellular Lipid Peroxidation Antioxidant Activity (CLPAA) assays. Compound 2 distinguished itself by showing potent activity, having a better antioxidant effect than luteolin in both the CAA and CLPAA assays and of quercetin in the CLPAA assay. Although several bromophenols are known to be potent antioxidants in biochemical assays, this is the first time their cellular antioxidant activity has been demonstrated.
从红色海藻Vertebrata lanosa 的提取物中分离得到了三种已知的溴酚类化合物，2,3-二溴-4,5-二羟基苯甲醛（1）、2,2',3-三溴-3',4,4',5-四羟基-6'-羟甲基二苯甲烷（2）和双（2,3-二溴-4,5-二羟基苯甲基）醚（3），以及一种新的化合物 5,5''-氧双（亚甲基）双（3-溴-4-（2',3'-二溴-4',5'-二羟基苯甲基）苯-1,2-二醇）（4）。使用一种生化和两种细胞测定法：氧自由基吸收能力（ORAC）、细胞抗氧化活性（CAA）和细胞脂质过氧化抗氧化活性（CLPAA）测定法，对这四种溴酚类化合物的抗氧化活性进行了研究。化合物 2 通过显示出强大的活性脱颖而出，在 CAA 和 CLPAA 测定中，其抗氧化效果优于木犀草素，在 CLPAA 测定中，其抗氧化效果优于槲皮素。虽然已知几种溴酚类化合物在生化测定中具有很强的抗氧化活性，但这是首次证明它们的细胞抗氧化活性。
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