Xu Nianjun, Fan Xiao, Yan Xiaojun, Li Xiancui, Niu Rongli, Tseng C K
Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, PR China.
Phytochemistry. 2003 Apr;62(8):1221-4. doi: 10.1016/s0031-9422(03)00004-9.
Two bromophenols, together with three known compounds, were isolated from the methanolic extract of the marine alga, Rhodomela confervoides. By means of MS and NMR spectroscopic analyses, they were identified as 3-bromo-4-[2,3-dibromo-4,5-dihydroxyphenyl] methyl-5-(hydroxymethyl) 1,2-benzenediol (1) and 3-bromo-4-[2,3-dibromo-4,5-dihydroxyphenyl] methyl-5- (ethoxymethyl) 1,2-benzenediol (2). Three known compounds were also isolated, namely 3-bromo-4-[2,3-dibromo-4,5-dihydroxyphenyl] methyl-5-(methoxymethyl) 1,2-benzenediol (3), 4,4'- methylenebis [5,6-dibromo-1,2-benzenediol] (4) and bis (2,3-dibromo-4,5-dihydroxybenzyl) ether (5). Compound 5 was the most active against five strains of bacteria with the MIC less than 70 microg/ml, while compounds 2, 3 and 4 exhibited moderate activity.
从海洋藻类纤细红节藻的甲醇提取物中分离出两种溴酚，以及三种已知化合物。通过质谱和核磁共振光谱分析，它们被鉴定为3-溴-4-[2,3-二溴-4,5-二羟基苯基]甲基-5-(羟甲基)-1,2-苯二酚(1)和3-溴-4-[2,3-二溴-4,5-二羟基苯基]甲基-5-(乙氧基甲基)-1,2-苯二酚(2)。还分离出三种已知化合物，即3-溴-4-[2,3-二溴-4,5-二羟基苯基]甲基-5-(甲氧基甲基)-1,2-苯二酚(3)、4,4'-亚甲基双5,6-二溴-1,2-苯二酚和双(2,3-二溴-4,5-二羟基苄基)醚(5)。化合物5对五株细菌的活性最强，其最低抑菌浓度小于70微克/毫升，而化合物2、3和4表现出中等活性。
