Institute of Food Science, Technology and Nutrition (ICTAN-CSIC), Spanish National Research Council (CSIC), José Antonio Nováis 10, 28040 Madrid, Spain.
Department of Chemical and Bioprocess Engineering, Pontificia Universidad Católica de Chile, Macul, Santiago 7810000, Chile.
Mar Drugs. 2020 Sep 30;18(10):501. doi: 10.3390/md18100501.
Phenolic compounds from marine organisms are far less studied than those from terrestrial sources since their structural diversity and variability require powerful analytical tools. However, both their biological relevance and potential properties make them an attractive group deserving increasing scientific interest. The use of efficient extraction and, in some cases, purification techniques can provide novel bioactives useful for food, nutraceutical, cosmeceutical and pharmaceutical applications. The bioactivity of marine phenolics is the consequence of their enzyme inhibitory effect and antimicrobial, antiviral, anticancer, antidiabetic, antioxidant, or anti-inflammatory activities. This review presents a survey of the major types of phenolic compounds found in marine sources, as well as their reputed effect in relation to the occurrence of dietary and lifestyle-related diseases, notably type 2 diabetes mellitus, obesity, metabolic syndrome, cancer and Alzheimer's disease. In addition, the influence of marine phenolics on gut microbiota and other pathologies is also addressed.
海洋生物中的酚类化合物的研究远少于陆地来源的酚类化合物，因为它们的结构多样性和可变性需要强大的分析工具。然而，它们的生物学相关性和潜在特性使它们成为一个值得越来越多科学关注的有吸引力的群体。使用有效的提取方法，在某些情况下，使用纯化技术可以提供新的生物活性物质，这些物质可用于食品、营养保健品、化妆品和制药应用。海洋酚类化合物的生物活性是其酶抑制作用以及抗菌、抗病毒、抗癌、抗糖尿病、抗氧化或抗炎活性的结果。本文综述了海洋来源中发现的主要类型的酚类化合物，以及它们在与饮食和生活方式相关的疾病（特别是 2 型糖尿病、肥胖症、代谢综合征、癌症和阿尔茨海默病）中的作用。此外，还讨论了海洋酚类化合物对肠道微生物群和其他疾病的影响。
