T 盒转录因子 T-bet 是一种独特类型的 B 细胞激活的关键因子，这种激活对于有效的清除病毒是必不可少的。
T-box transcription factor T-bet, a key player in a unique type of B-cell activation essential for effective viral clearance.
机构信息
Howard Hughes Medical Institute, Denver, CO 80206, USA.
出版信息
Proc Natl Acad Sci U S A. 2013 Aug 20;110(34):E3216-24. doi: 10.1073/pnas.1312348110. Epub 2013 Aug 6.
Abstract
IgG2a is known to be the most efficient antibody isotype for viral clearance. Here, we demonstrate a unique pathway of B-cell activation, leading to IgG2a production, and involving synergistic stimulation via B-cell antigen receptors, toll-like receptor 7 (TLR7), and IFNγ receptors on B cells. This synergistic stimulation leads to induction of T-box transcription factor T-bet expression in B cells, which, in turn, drives expression of CD11b and CD11c on B cells. T-bet/CD11b/CD11c positive B cells appear during antiviral responses and produce high titers of antiviral IgG2a antibodies that are critical for efficient viral clearance. The results thus demonstrate a previously unknown role for T-bet expression in B cells during viral infections. Moreover, the appearance of T-bet(+) B cells during antiviral responses and during autoimmunity suggests a possible link between these two processes.
摘要
IgG2a 是已知清除病毒最有效的抗体同种型。在这里，我们展示了一种独特的 B 细胞激活途径，导致 IgG2a 的产生，并涉及 B 细胞上的 B 细胞抗原受体、Toll 样受体 7（TLR7）和 IFNγ 受体的协同刺激。这种协同刺激导致 T 框转录因子 T 细胞在 B 细胞中表达的诱导，反过来又驱动 B 细胞上 CD11b 和 CD11c 的表达。T-bet/CD11b/CD11c 阳性 B 细胞在抗病毒反应期间出现，并产生对有效病毒清除至关重要的高滴度抗病毒 IgG2a 抗体。因此，这些结果证明了 T-bet 在病毒感染期间 B 细胞中的一个以前未知的作用。此外，在抗病毒反应期间和自身免疫期间 T-bet(+)B 细胞的出现表明这两个过程之间可能存在联系。
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