与年龄相关的 B 细胞：它们是否是理解为什么自身免疫性疾病在女性中更为普遍的关键？
Age-associated B cells: are they the key to understanding why autoimmune diseases are more prevalent in women?
出版信息
Expert Rev Clin Immunol. 2012 Jan;8(1):5-7. doi: 10.1586/eci.11.83.
Abstract
“A significant body of research suggests roles for sex hormones as well as genetic factors in the development and/or progression of autoimmunity.”
摘要
大量研究表明，性激素和遗传因素在自身免疫的发生和/或进展中起作用。
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本文引用的文献
1
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Blood. 2011 Aug 4;118(5):1294-304. doi: 10.1182/blood-2011-01-330530. Epub 2011 May 11.
2
Toll-like receptor 7 (TLR7)-driven accumulation of a novel CD11c⁺ B-cell population is important for the development of autoimmunity.Toll 样受体 7（TLR7）驱动的新型 CD11c⁺B 细胞群体的积累对于自身免疫的发展很重要。
Blood. 2011 Aug 4;118(5):1305-15. doi: 10.1182/blood-2011-01-331462. Epub 2011 May 4.
3
Complement receptor 2/CD21- human naive B cells contain mostly autoreactive unresponsive clones.补体受体 2/CD21- 人幼稚 B 细胞中主要包含自身反应性无应答克隆。
Blood. 2010 Jun 17;115(24):5026-36. doi: 10.1182/blood-2009-09-243071. Epub 2010 Mar 15.
4
Genetic and hormonal factors in female-biased autoimmunity.女性偏倚自身免疫的遗传和激素因素。
Autoimmun Rev. 2010 May;9(7):494-8. doi: 10.1016/j.autrev.2010.02.008. Epub 2010 Feb 6.
5
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Proc Natl Acad Sci U S A. 2009 Aug 11;106(32):13451-6. doi: 10.1073/pnas.0901984106. Epub 2009 Jul 29.
6
A role for sex chromosome complement in the female bias in autoimmune disease.性染色体组成在自身免疫性疾病女性偏多现象中的作用。
J Exp Med. 2008 May 12;205(5):1099-108. doi: 10.1084/jem.20070850. Epub 2008 Apr 28.
7
Identification of candidate genes that influence sex hormone-dependent disease phenotypes in mouse lupus.鉴定影响小鼠狼疮中性激素依赖性疾病表型的候选基因。
Genes Immun. 2008 Jan;9(1):47-56. doi: 10.1038/sj.gene.6364447. Epub 2007 Nov 29.
8
A cross-species comparison of X-chromosome inactivation in Eutheria.真兽亚纲中X染色体失活的跨物种比较。
Genomics. 2007 Oct;90(4):453-63. doi: 10.1016/j.ygeno.2007.07.002. Epub 2007 Aug 28.
9
Nucleic acid agonists for Toll-like receptor 7 are defined by the presence of uridine ribonucleotides.Toll样受体7的核酸激动剂由尿苷核糖核苷酸的存在来定义。
Eur J Immunol. 2006 Dec;36(12):3256-67. doi: 10.1002/eji.200636617.
10
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