Hospital Nacional de Parapléjicos, Servicio de Salud de Castilla-La Mancha, Toledo, Spain.
PLoS One. 2013 Jul 29;8(7):e69655. doi: 10.1371/journal.pone.0069655. Print 2013.
Sensory deafferentation produces extensive reorganization of the corresponding deafferented cortex. Little is known, however, about the role of the adjacent intact cortex in this reorganization. Here we show that a complete thoracic transection of the spinal cord immediately increases the responses of the intact forepaw cortex to forepaw stimuli (above the level of the lesion) in anesthetized rats. These increased forepaw responses were independent of the global changes in cortical state induced by the spinal cord transection described in our previous work (Aguilar et al., J Neurosci 2010), as the responses increased both when the cortex was in a silent state (down-state) or in an active state (up-state). The increased responses in the intact forepaw cortex correlated with increased responses in the deafferented hindpaw cortex, suggesting that they could represent different points of view of the same immediate state-independent functional reorganization of the primary somatosensory cortex after spinal cord injury. Collectively, the results of the present study and of our previous study suggest that both state-dependent and state-independent mechanisms can jointly contribute to cortical reorganization immediately after spinal cord injury.
感觉传入缺失会导致相应去传入皮质广泛重组。然而，关于相邻完整皮质在这种重组中的作用知之甚少。本文中，我们发现，在麻醉大鼠中，脊髓完全胸部横断立即增加了完整前爪皮质对前爪刺激（损伤水平以上）的反应。这些增强的前爪反应与我们之前工作中描述的脊髓横断引起的皮质整体状态变化无关（Aguilar 等人，J Neurosci 2010），因为当皮质处于静息状态（下状态）或活跃状态（上状态）时，反应都会增强。完整前爪皮质中的增强反应与去传入后爪皮质中的增强反应相关，表明它们可能代表脊髓损伤后初级体感皮质相同的即时状态独立功能重组的不同观点。总之，本研究和我们之前研究的结果表明，状态依赖和状态独立机制都可以共同促成脊髓损伤后皮质的快速重组。
