Department of Gastroenterology and Hepatology, Radboud University Medical Center, Nijmegen, The Netherlands.
PLoS One. 2013 Jul 29;8(7):e69876. doi: 10.1371/journal.pone.0069876. Print 2013.
Over the last decades important risk factors for gastrointestinal symptoms have shifted, which may have changed its population prevalence. The aim of this study was to assess the current prevalence of gastrointestinal symptoms, appraise associated factors and assess health-related quality of life in the general population.
A total of 51,869 questionnaires were sent to a representative sample of the Dutch adult general population in December 2008. Demographic characteristics, gastrointestinal symptoms, health-related quality of life, medication use and co-morbidity were reported. We used multivariable logistic regression analysis to determine factors associated with gastrointestinal symptoms.
A total of 18,317 questionnaires were returned, and 16,758 were eligible for analysis. Prevalence of gastrointestinal symptoms was 26%. Most frequent symptoms were bloating (63%), borborygmi (60%) and flatulence (71%). Female gender (adjusted OR (aOR) 1.59, 95% CI 1.43-1.77), asthma/COPD (aOR 1.47, 95% CI 1.21-1.79), use of paracetamol (aOR 1.33, 95% CI 1.20-1.47), antidepressants (aOR 1.56, 95% CI 1.22-2.00) and acid-suppressive medication were independently associated with presence of gastrointestinal symptoms. Age over 65 years (aOR 0.75, 95% CI 0.65-0.87), and use of statins (aOR 0.75, 95% CI 0.61-0.93) were associated with a lower prevalence of gastrointestinal symptoms. Respondents with gastrointestinal symptoms had a lower mean health-related quality of life of 0.81 (SD = 0.21) compared to 0.92 (SD = 0.14) for persons without gastrointestinal symptoms (P<0.01).
Prevalence of gastrointestinal symptoms in the Dutch community is high and associated with decreased health-related quality of life.
在过去的几十年中，胃肠道症状的重要危险因素发生了变化，这可能导致其在人群中的患病率发生了变化。本研究旨在评估一般人群中胃肠道症状的当前患病率，评估相关因素，并评估与健康相关的生活质量。
2008 年 12 月，我们向荷兰成年人群的代表性样本发送了总共 51869 份问卷。报告了人口统计学特征、胃肠道症状、与健康相关的生活质量、药物使用和合并症。我们使用多变量逻辑回归分析来确定与胃肠道症状相关的因素。
共收回 18317 份问卷，其中 16758 份符合分析条件。胃肠道症状的患病率为 26%。最常见的症状是腹胀（63%）、肠鸣音（60%）和嗳气（71%）。女性（调整后的比值比（aOR）1.59，95%置信区间 1.43-1.77）、哮喘/COPD（aOR 1.47，95%置信区间 1.21-1.79）、使用扑热息痛（aOR 1.33，95%置信区间 1.20-1.47）、抗抑郁药（aOR 1.56，95%置信区间 1.22-2.00）和酸抑制药物与胃肠道症状的存在独立相关。65 岁以上（aOR 0.75，95%置信区间 0.65-0.87）和使用他汀类药物（aOR 0.75，95%置信区间 0.61-0.93）与胃肠道症状的低患病率相关。有胃肠道症状的受访者的健康相关生活质量平均得分较低，为 0.81（标准差=0.21），而无胃肠道症状的受访者为 0.92（标准差=0.14）（P<0.01）。
荷兰社区胃肠道症状的患病率较高，与健康相关的生活质量下降有关。
