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被动吸烟与 2 型糖尿病风险：前瞻性队列研究的荟萃分析。

Passive smoking and risk of type 2 diabetes: a meta-analysis of prospective cohort studies.

机构信息

School of Public Health, Wuhan University, Wuhan, PR China.

出版信息

PLoS One. 2013 Jul 26;8(7):e69915. doi: 10.1371/journal.pone.0069915. Print 2013.

DOI:10.1371/journal.pone.0069915
PMID:23922856
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3724674/
Abstract

BACKGROUNDS/OBJECTIVE: The prevalence of diabetes is increasing rapidly all over the world. However, studies on passive smoking and type 2 diabetes have not been systematically assessed. Therefore, we conducted a meta-analysis to explore whether an association exists between passive smoking and risk of type 2 diabetes.

METHODS

We searched PubMed, EMBASE, Cochrane library and Web of Science up to April 9(th), 2013, to identify prospective cohort studies that assessed passive smoking and risk of type 2 diabetes. The fixed-effect model was used to calculate the overall relative risk (RR).

RESULT

4 prospective cohort studies were included for analysis, with a total of 112,351 participants involved. The pooled RR was 1.28 (95% confidence interval (CI) 1.14 to 1.44) comparing those who were exposed to passive smoking with those who were not. Subgroup, sensitivity analysis and publication bias test suggested the overall result of this analysis was robust.

CONCLUSIONS

Passive smoking is associated with a significantly increased risk of type 2 diabetes. Further well-designed studies are warranted to confirm this association.

摘要

背景/目的：糖尿病的患病率在全球范围内迅速上升。然而，有关被动吸烟与 2 型糖尿病之间关系的研究尚未进行系统评估。因此，我们进行了一项荟萃分析，以探讨被动吸烟与 2 型糖尿病风险之间是否存在关联。

方法

我们检索了 PubMed、EMBASE、Cochrane 图书馆和 Web of Science，截至 2013 年 4 月 9 日，以确定评估被动吸烟与 2 型糖尿病风险的前瞻性队列研究。使用固定效应模型计算总体相对风险（RR）。

结果

纳入了 4 项前瞻性队列研究，共涉及 112351 名参与者。与未接触被动吸烟的人相比，接触被动吸烟的人患 2 型糖尿病的 RR 为 1.28（95%置信区间 1.14 至 1.44）。亚组、敏感性分析和发表偏倚检验表明，该分析的总体结果是稳健的。

结论

被动吸烟与 2 型糖尿病的风险显著增加相关。需要进一步设计良好的研究来证实这种关联。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3ac/3724674/56978d807ea1/pone.0069915.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3ac/3724674/4507cad7ede2/pone.0069915.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3ac/3724674/56978d807ea1/pone.0069915.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3ac/3724674/4507cad7ede2/pone.0069915.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3ac/3724674/56978d807ea1/pone.0069915.g002.jpg

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